General
Preferred name
FENSPIRIDE
Synonyms
FENSPIRIDE HYDROCHLORIDE ()
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-phenylethyl)- ()
Fenspiride HCl ()
Pneumorel ()
Fluiden ()
Decaspiride ()
Fenspiride (Hydrochloride) ()
NDR-5998A ()
NSC-757825 ()
NAT-333 ()
Eurespal ()
Fenspirida ()
Fenspiride-d5 ()
P&D ID
PD009425
CAS
5053-08-7
5053-06-5
1246911-67-0
Tags
available
drug candidate
drug
Drug Status
approved
withdrawn
experimental
Max Phase
4.0
Drug indication
Airway obstruction
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3].
PRICE 29
DESCRIPTION alpha-Adrenoceptor antagonist; NSAID (LOPAC library)
DESCRIPTION Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of chronic and acute inflammatory diseases of ENT organs and the respiratory tract (like sinusitis, tracheobronchitis, otitis, laryngitis, and rhinopharyngitis), and for maintenance therapy of asthma. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
18
Cayman Chemical Bioactives
25512
33711
ChEMBL Approved Drugs
CHEMBL576127
ChEMBL Drugs
CHEMBL1256849
CHEMBL576127
Drug Repurposing Hub
DrugBank
DB08979
DrugCentral
1163
DrugCentral Approved Drugs
1163
DrugMatrix
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
HY-A0027
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Fenspiride-hcl
TargetMol Bioactive Compound Library
T0383
The Spectrum Collection
Withdrawn 2.0
DB08979
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
260.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
1.8
TPSA
41.57
Fraction CSP3
0.53
Chiral centers
0.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha
Pathway
GPCR/G protein
Immunology/Inflammation
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Indication
asthma, otitis, sinusitis, rhinopharyngitis, laryngitis
Disease Area
pulmonary, otolaryngology
MOA
bronchodilator
ATC
R03BX01
R03DX03
Toxicity type
NULL
Target
Histamine Receptor
Phosphodiesterase (PDE)
PDE
Adrenergic Receptor
PDE3
PDE4
Source data