General
Preferred name
CLOPERASTINE
Synonyms
CLOPERASTINE HYDROCHLORIDE ()
Cloperastine (HCl) ()
HT-11 hydrochloride ()
Cloperastine (hydrochloride) ()
CLOPERASTINE HYDROCLORIDE ()
Cloperastina ()
NSC-758635 ()
HT-11 ()
P&D ID
PD009413
CAS
3703-76-2
132301-89-4
14984-68-0
Tags
available
drug
nuisance
Drug Status
approved
experimental
investigational
Max Phase
2.0
Drug indication
Cough
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM[1].
DESCRIPTION Cloperastine hydrochloride is a blocker of sodium channel protein type 8. (Enamine Bioactive Compounds)
DESCRIPTION Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
4
Compound Sets
15
ChEMBL Drugs
CHEMBL415087
Drug Repurposing Hub
DrugBank
DB09002
DrugCentral
707
DrugCentral Approved Drugs
707
DrugMatrix
Enamine Bioactive Compounds
EBC-03905
MedChem Express Bioactive Compound Library
HY-B2133
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
cloperastine-hydrochloride
TargetMol Bioactive Compound Library
T0723
The Spectrum Collection
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
329.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
4.93
TPSA
12.47
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
HT
Potassium Channel
Histamine Receptor
MOA
Potassium Channel antagonist
Pathway
Membrane Transporter/Ion Channel
GPCR/G protein
Neuroscience
Source data