General
Preferred name
BROMHEXINE
Synonyms
BROMHEXINE HYDROCHLORIDE ()
Bromhexine HCl ()
Auxit ()
Bisolvon ()
Bromhexine (hydrochloride) ()
NA 274 ()
Brombenzonium ()
NA-274 ()
NSC-758383 ()
Bromehexine hydrochloride ()
Fluibron ()
P&D ID
PD009404
CAS
611-75-6
3572-43-8
32184-12-6
Tags
prodrug
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Mucolytic
Expectorant
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Bromhexine is a widely used mucolytic (expectorant) drug. In response to the SARS-CoV-2 pandemic of 2019/20 it was investigated as an add-on treatment for patients with COVID-19 . In addition to its mucolytic activity, bromhexine may also inhibit the human protease TMPRSS2 that is exploited by certain coronaviruses for spike (S) protein priming, thus reducing the viruses' infection mechanism .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
374.0
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
4.56
TPSA
29.26
Fraction CSP3
0.57
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Reactive Oxygen Species
HIV
SARS-CoV
Pathway
Metabolic Enzyme/Protease
NF-¦ÊB
Immunology/Inflammation
Autophagy
Anti-infection
Indication
chest congestion
MOA
mucolytic agent
Source data
