General
Preferred name
BROMHEXINE
Synonyms
BROMHEXINE HYDROCHLORIDE ()
Bromhexine HCl ()
Auxit ()
Bisolvon ()
Bromhexine (hydrochloride) ()
NA 274 ()
NA-274 ()
Brombenzonium ()
NSC-758383 ()
Bromehexine hydrochloride ()
Fluibron ()
Bromhexina ()
P&D ID
PD009404
CAS
611-75-6
3572-43-8
32184-12-6
Tags
available
prodrug
drug candidate
drug
Drug Status
approved
investigational
Max Phase
3.0
1.0
Drug indication
Malaria
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 ¦ÌM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions[1][2][3][4].
DESCRIPTION Bromhexine is a widely used mucolytic (expectorant) drug. In response to the SARS-CoV-2 pandemic of 2019/20 it was investigated as an add-on treatment for patients with COVID-19 . In addition to its mucolytic activity, bromhexine may also inhibit the human protease TMPRSS2 that is exploited by certain coronaviruses for spike (S) protein priming, thus reducing the viruses' infection mechanism . (GtoPdb)
DESCRIPTION Bromhexine HCl is an expectorant/mucolytic agent which works by dissolving hard phlegm. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. (Enamine Bioactive Compounds)
DESCRIPTION Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (TargetMol Bioactive Compound Library)
Compound Sets
17
Cayman Chemical Bioactives
37900
ChEMBL Drugs
CHEMBL1319139
CHEMBL253376
Drug Repurposing Hub
DrugBank
DB09019
DrugBank Approved Drugs
DB09019
DrugCentral
402
DrugCentral Approved Drugs
402
Enamine Bioactive Compounds
EBC-07637
Enamine BioReference Compounds
Guide to Pharmacology
11218
MedChem Express Bioactive Compound Library
HY-B0372A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
bromhexine-hydrochloride
bromhexine
TargetMol Bioactive Compound Library
T0828
The Spectrum Collection
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
374.0
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
4.56
TPSA
29.26
Fraction CSP3
0.57
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Reactive Oxygen Species
HIV
SARS-CoV
Pathway
Metabolic Enzyme/Protease
NF-¦ÊB
Immunology/Inflammation
Autophagy
Microbiology/virology
Proteases/Proteasome
Anti-infection
Indication
chest congestion
MOA
mucolytic agent
Source data