General
Preferred name
ELIGLUSTAT
Synonyms
Genz 99067 ()
GENZ-112638 ()
Eliglustat Tartrate ()
Eliglustat (hemitartrate) ()
Eliglustat hemitartrate ()
Genz-112638, Eliglustat tartrate, Cerdelga ()
GENZ-99067 ()
GENZ 99067 ()
Cerdelga ()
GENZ 112638 ()
Eliglustat (hemitartrate) ()
Eliglustat-d15 (tartrate) ()
P&D ID
PD009396
CAS
491833-29-5
1000191-50-3
928659-70-5
Tags
available
drug
Approved by
EMA
FDA
First approval
2014
Drug Status
investigational
approved
Drug indication
Metabolic disorder
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Eliglustat is indicated for the long-term treatment of type 1 Gaucher disease in adult patients who are CYP2D6 extensive metabolizers (EMs), intermediate metabolizers (IMs), or poor metabolizers (PMs) as detected by an FDA-cleared test.[label]
DESCRIPTION The marketed formulation contains eliglustat tartrate (PubChem CID 52918379). (GtoPdb)
Compound Sets
22
AdooQ Bioactive Compound Library
A12386
Cayman Chemical Bioactives
21487
30167
ChEMBL Approved Drugs
CHEMBL2110588
CHEMBL4297066
ChEMBL Drugs
CHEMBL2110588
CHEMBL4297066
Drug Repurposing Hub
DrugBank
DB09039
DrugBank Approved Drugs
DB09039
DrugCentral
4834
DrugCentral Approved Drugs
4834
DrugMAP
DMSRZAO
DrugMAP Approved Drugs
DMSRZAO
EU-OPENSCREEN Bioactive Compound Library
EOS101691
Guide to Pharmacology
7536
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2110588
Mcule NIBR MoA Box Subset
MCULE-8753045692
MedChem Express Bioactive Compound Library
HY-14885
HY-14885A
NCATS Inxight Approved Drugs
DR40J4WA67
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
eliglustat
eliglustat-hemitartrate
TargetMol Bioactive Compound Library
T3663
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
404.27
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
11
Ring Count
3
Aromatic Ring Count
1
cLogP
3.43
TPSA
71.03
Fraction CSP3
0.7
Chiral centers
2.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Target
glucosylceramide synthase
UGCG
Member status
member
Indication
Gaucher disease
MOA
glycosyl transferase inhibitor
Source data