General
Preferred name
CHOLIC ACID
Synonyms
SodiumCholate ()
Cholanic acid ()
Cholate ()
Colalin ()
Sodium cholate ()
Orphacol ()
Kybella ()
Deoxycholic acid sodium salt ()
Cholic acid (sodium) ()
Cholic acid sodium ()
Cholic Acid-d4 ()
Kolbam ()
E1000 ()
NSC-6135 ()
CHOLALIC ACID ()
Cholbam ()
Cholic Acid MaxSpec® Standard ()
Cholic Acid-24-13C ()
Cholic acid sodium hydrate ()
P&D ID
PD009388
CAS
73163-53-8
10321-98-9
81-25-4
361-09-1
116380-66-6
52886-36-9
206986-87-0
Tags
available
drug
Approved by
EMA
FDA
PMDA
First approval
2013
Drug indication
Synthesis disorder
Hepatic steatosis
Peroxisomal disorder
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cholic acid is a primary bile acid. Along with , it is one of the two major bile acids synthesized from cholesterol in the liver.
(GtoPdb)
PRICE
29
DESCRIPTION
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active[1][2].
PRICE
29
PRICE
29
DESCRIPTION
Cholic acid sodium hydrate is a natural and orally active bile acid that is synthesized primarily by the liver and secreted into the bile, where it plays an important role in the digestive process, aiding in the absorption of fats by emulsifying them, as well as participating in the excretion of cholesterol and regulating the metabolism of bile acids.
DESCRIPTION
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. It is an agonist G-protein coupled bile acid receptor 1.
(Enamine Bioactive Compounds)
DESCRIPTION
Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
26
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Mcule NIBR MoA Box Subset
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
103
Molecular Weight
408.29
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
0
cLogP
3.45
TPSA
97.99
Fraction CSP3
0.96
Chiral centers
11.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
HIV
ADH1C, CES1, COX4I1, COX5A, COX5B, COX6A2, COX6B1, COX6C, COX7A1, COX7B, COX7C, COX8A, ESRRG, FABP6, FECH, GPBAR1, MT-CO1, MT-CO2, MT-CO3, PLA2G1B
Member status
virtual
MOA
Cholesterol-7-alpha-hydroxylase product and feedback inhibitor
bile acid
Indication
bile acid synthesis disorders, peroxisomal disorders, Zellweger syndrome
Disease Area
gastroenterology, neurology/psychiatry, genetics
Biosynthetic Origin
Terpenoid (Steroid)
Therapeutic Indication
Inborn Errors of Bile Synthesis
Dermatological Disorders
Therapeutic Class
Metabolic Disorders
Pathway
Metabolism
Microbiology/virology
Proteases/Proteasome
Metabolic Enzyme/Protease
Recommended Cell Concentration
None
Source data
