General
Preferred name
ACETYLCHOLINE
Synonyms
ACETYLCHOLINE CHLORIDE ()
Ach ()
ACh chloride ()
Pilofrin ()
Acetylcolina ()
Acetylcholine Hydrobromide ()
Miochol ()
Acetylcholine (iodide) ()
Acetylcholine (chloride) ()
ACh (iodide) ()
ACh (chloride) ()
ACETYLCHOLINE IODIDE ()
Acetylcholine bromide ()
Acetylcholine chloride for injection ()
Miphtel ()
Chlorure d'acetylcholine ()
Miochol-E ()
NSC-755845 ()
Choline acetate (ester) chloride ()
Cloruro de acetilcolina ()
[3H]acetylcholine ()
Acetylcholine ()
P&D ID
PD009386
CAS
60-31-1
51-84-3
1784-29-8
2260-50-6
66-23-9
Tags
available
drug
Approved by
FDA
First approval
1973
Drug indication
Miosis
Cataract
Ischemia
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].
PRICE
29
DESCPRITION
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
DESCRIPTION
The position of the tritiated hydrogen atom is not specified in the available literature therefore is not shown in the structure here.
(GtoPdb)
DESCRIPTION
Acetylcholine iodide is a muscarinic receptor modulator. Acetylcholine iodide specifically binds to muscarinic receptors, inhibits sodium absorption, and induces chloride secretion. Acetylcholine iodide changes intestinal ion transport, enhances intestinal secretory function, induces or maintains mammary gland development and lactation. Acetylcholine iodide can be used for intestinal ion transport regulation and mammary gland physiological function research[1][2][3].
PRICE
29
PRICE
29
DESCRIPTION
Acetylcholine is an organic molecule that acts as a neurotransmitter in many organisms, including humans.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Acetylcholine chloride is a neurotransmitter. It is a potent cholinergic agonist.
(Enamine Bioactive Compounds)
DESCRIPTION
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogenous compound acetylcholine. Administered as an ophthalmic solution, this drug stimulates the cholinoceptors in the sphincter muscle of the iris, causing the pupil to constrict.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Acetylcholine bromide is the bromide salt of acetylcholine. It is an neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
32
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
108
Molecular Weight
146.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
0.26
TPSA
26.3
Fraction CSP3
0.86
Chiral centers
0.0
Largest ring
0.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChR
Calcium Channel
Endogenous Metabolite
nAChR
ACHE, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CHRNA2
mAChR
Indication
drowsiness, fatigue, headache, indigestion, chest congestion
Disease Area
neurology/psychiatry, gastroenterology, pulmonary
MOA
acetylcholine receptor agonist
Pathway
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
GPCR/G protein
Metabolic Enzyme/Protease
Neuronal Signaling
Therapeutic Class
Cardiovascular Agents
Source data
