General
Preferred name
DRONEDARONE
Synonyms
DRONEDARONE HYDROCHLORIDE ()
Dronedarone HCl ()
SR33589 ()
SR 33589 ()
Dronedarone HCl ()
Dronedarone (Hydrochloride) ()
Multaq ()
SR33598B ()
SR-33598B ()
SR-33589 ()
Dronedarone-d6 (hydrochloride) ()
P&D ID
PD009359
CAS
141626-36-0
141625-93-6
1329809-23-5
Tags
natural product
drug
available
Approved by
FDA
First approval
2009
Drug Status
approved
Drug indication
Angina pectoris
Atrial fibrillation
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dronedarone is a class III antiarrhythmic drug. It is a noniodinated analogue of . The marketed formulation contains the hydrochloride salt (PubChem CID 219025). (GtoPdb)
DESCRIPTION Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
26
AdooQ Bioactive Compound Library
A11389
Axon Medchem Screening Library
3450
BOC Sciences Bioactive Compounds
dronedarone-cas-141626-36-0-item-84-461955
Cayman Chemical Bioactives
9000543
31787
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1201729
CHEMBL184412
ChEMBL Drugs
CHEMBL1201729
CHEMBL184412
Drug Repurposing Hub
DrugBank
DB04855
DrugBank Approved Drugs
DB04855
DrugCentral
4112
DrugCentral Approved Drugs
4112
DrugMAP
DMA8FS5
DrugMAP Approved Drugs
DMA8FS5
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7465
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201729
CHEMBL184412
MedChem Express Bioactive Compound Library
HY-75839
HY-A0016
NCATS Inxight Approved Drugs
JQZ1L091Y2
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
dronedarone-hcl-multaq
dronedarone
TargetMol Bioactive Compound Library
T1073
T7056
The Spectrum Collection
External IDs
54
Properties
(calculated by RDKit )
Molecular Weight
556.3
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
18
Ring Count
3
Aromatic Ring Count
3
cLogP
7.05
TPSA
88.85
Fraction CSP3
0.52
Chiral centers
0.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
voltage-gated potassium channel blocker
voltage-gated sodium channel blocker
voltage-gated calcium channel blocker
Potassium Channel inhibitor
Sodium Channel inhibitor
Calcium Channel inhibitor
Adrenergic Receptor antagonist
Target
Sodium channel alpha subunit
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Voltage-gated L-type calcium channel
Inward rectifier potassium channel 2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Adrenergic Receptor
Calcium Channel
Potassium Channel
Sodium Channel
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNB1, CACNB2, CACNB3, CACNB4, KCNA5, KCNH2, KCNK2, SCN1A
Ca2+/K+/Na+ blocker
Cytochrome P450
mAChR
Calcium Channel,Potassium Channel,Sodium Channel
Pathway
Neuroscience
Membrane Transporter/Ion Channel
GPCR/G protein
Autophagy
Metabolic Enzyme/Protease
Neuronal Signaling
Indication
atrial fibrillation (AF)
Source data