General
Preferred name
NEBIVOLOL
Synonyms
NEBIVOLOL HYDROCHLORIDE ()
R 065824 hydrochloride ()
Nebivolol HCl ()
R-65824 ()
R067555 ()
Bystolic ()
RO67555 ()
R-067555 ()
Nebivolol hydrochloride component of byvalson ()
R65,824 ()
Narbivolol ()
Hypoloc ()
Nebivolol component of byvalson ()
Nebilet ()
(±)-Nebivolol-d4 (hydrochloride) ()
P&D ID
PD009358
CAS
118457-14-0
104365-59-5
99200-09-6
152520-56-4
2701283-32-9
Tags
available
drug
biased GPCR ligand
Approved by
FDA
First approval
2007
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 35
DESCRIPTION Nebivolol is a β-blocker, selective for β1-adrenoceptors.
Marketed formulations may contain nebivolol hydrochloride (PubChem CID ). (GtoPdb)
DESCRIPTION Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients. (TargetMol Bioactive Compound Library)
Compound Sets
22
BiasDB
Nebivolol
Cayman Chemical Bioactives
26659
ChEMBL Approved Drugs
CHEMBL1201731
CHEMBL434394
ChEMBL Drugs
CHEMBL1201731
CHEMBL434394
Concise Guide to Pharmacology 2017/18
7246
Concise Guide to Pharmacology 2019/20
7246
Concise Guide to Pharmacology 2021/22
7246
Concise Guide to Pharmacology 2023/24
7246
DrugBank
DB04861
DrugBank Approved Drugs
DB04861
DrugCentral
1887
DrugCentral Approved Drugs
1887
DrugMAP
DM7F1PA
DrugMAP Approved Drugs
DM7F1PA
DrugMatrix
Guide to Pharmacology
7246
Ki Database
Nebivolol
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T0154
The Spectrum Collection
VGSC-DB
NA0094
NA0095
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
405.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
2.36
TPSA
70.95
Fraction CSP3
0.45
Chiral centers
4.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Adrenergic Receptor
Apoptosis
β1-adrenoceptor
Pathway
GPCR/G protein
Neuroscience
Therapeutic Class
Antihypertensive Agents
VGSC Target
Nav1.5
Source data