General
Preferred name
NEBIVOLOL
Synonyms
NEBIVOLOL HYDROCHLORIDE ()
Nebivolol HCl ()
R067555 ()
Bystolic ()
R-067555 ()
RO67555 ()
Narbivolol ()
R65,824 ()
Hypoloc ()
Nebilet ()
R-65824 ()
(±)-Nebivolol-d4 (hydrochloride) ()
P&D ID
PD009358
CAS
118457-14-0
104365-59-5
99200-09-6
2701283-32-9
Tags
drug
natural product
biased GPCR ligand
available
Approved by
FDA
First approval
2007
Drug Status
investigational
approved
Drug indication
Antihypertensive (beta-blocker)
Hypertension
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nebivolol is a β-blocker, selective for β1-adrenoceptors.
Marketed formulations may contain nebivolol hydrochloride (PubChem CID ). (GtoPdb)
Compound Sets
21
BiasDB
Nebivolol
Cayman Chemical Bioactives
26659
ChEMBL Approved Drugs
CHEMBL1201731
CHEMBL434394
ChEMBL Drugs
CHEMBL1201731
CHEMBL434394
Concise Guide to Pharmacology 2017/18
7246
Concise Guide to Pharmacology 2019/20
7246
Concise Guide to Pharmacology 2021/22
7246
Concise Guide to Pharmacology 2023/24
7246
DrugBank
DB04861
DrugBank Approved Drugs
DB04861
DrugCentral
1887
DrugCentral Approved Drugs
1887
DrugMAP
DM7F1PA
DrugMAP Approved Drugs
DM7F1PA
DrugMatrix
Guide to Pharmacology
7246
Ki Database
Nebivolol
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
VGSC-DB
NA0094
NA0095
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
405.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
2.36
TPSA
70.95
Fraction CSP3
0.45
Chiral centers
4.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antihypertensive Agents
VGSC Target
Nav1.5
Source data