General
Preferred name
lorcaserin
Synonyms
APD-356 ()
R-Lorcaserin hydrochloride hemihydrate ()
Lorcaserin HCl ()
LORCASERIN HYDROCHLORIDE ()
Lorqess ()
Belviq XR ()
Belviq ()
APD356 ()
Lorcaserin (Hydrochloride) ()
Lorcaserin (hydrochloride) (CRM) ()
P&D ID
PD009356
CAS
856681-05-5
846589-98-8
616202-92-7
Tags
drug
biased GPCR ligand
available
Approved by
FDA
First approval
2012
Drug Status
approved
withdrawn
Drug indication
Obesity
Drug abuse
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Orally available and CNS active drug .
ROE Lorcaserin is eliminated by hepatic metabolism, and the metabolites are eliminated mostly in the urine (92.3%) and some through feces (2.2%). ;
TOXICITY Most common adverse reactions include hypoglycemia (diabetic patients), headache, ; back pain,fatigue, decrease in lymphocytes,upper respiratory tract infection, and nasopharyngitis. Moreover, the safety and efficacy of coadministration with other weight loss products has not been established, and cardiovascular effects on mortality and morbidity have not been established.
DESCRIPTION Lorcaserin is a selective, orally available and CNS active serotonin 2C receptor agonist that modulates appetite . Cardiovascular safety in obese/overweight patients was reported by Bohula et al. (2018) .
Clinical formulations contain lorcaserin hydrochloride (PubChem CID 11673085). (GtoPdb)
Compound Sets
18
BiasDB
Lorcaserin
Cayman Chemical Bioactives
15521
19247
ChEMBL Approved Drugs
CHEMBL2095211
CHEMBL360328
ChEMBL Drugs
CHEMBL2095211
CHEMBL360328
Concise Guide to Pharmacology 2017/18
2941
Concise Guide to Pharmacology 2019/20
2941
Concise Guide to Pharmacology 2021/22
2941
Concise Guide to Pharmacology 2023/24
2941
DrugBank
DB04871
DrugBank Approved Drugs
DB04871
DrugCentral
4374
DrugCentral Approved Drugs
4374
DrugMAP
DMG6OYJ
DrugMAP Approved Drugs
DMG6OYJ
Guide to Pharmacology
2941
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL360328
ReFrame library
TargetMol Bioactive Compound Library
T6572
T8757
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
195.08
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
2.59
TPSA
12.03
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
7.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Target
5-HT2C
5-HT2C (Human)
5-HT2C (Rat)
MOA
5-HT Receptor agonist
Source data