General
Preferred name
lorcaserin
Synonyms
LORCASERIN HYDROCHLORIDE ()
Lorcaserin (Hydrochloride) ()
Lorcaserin (hydrochloride) (CRM) ()
Lorcaserin HCl ()
APD-356 ()
APD356 ()
Lorqess ()
Lorcaserina ()
ADP356 ()
Lorcaserine ()
ADP-356 ()
P&D ID
PD009356
CAS
846589-98-8
616202-92-7
Tags
available
drug
biased GPCR ligand
Approved by
FDA
First approval
2012
Drug indication
Obesity
Drug abuse
Cardiovascular disease
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Orally available and CNS active drug .
ROE Lorcaserin is eliminated by hepatic metabolism, and the metabolites are eliminated mostly in the urine (92.3%) and some through feces (2.2%). ;
TOXICITY Most common adverse reactions include hypoglycemia (diabetic patients), headache, ; back pain,fatigue, decrease in lymphocytes,upper respiratory tract infection, and nasopharyngitis. Moreover, the safety and efficacy of coadministration with other weight loss products has not been established, and cardiovascular effects on mortality and morbidity have not been established.
DESCRIPTION Lorcaserin is a selective, orally available and CNS active serotonin 2C receptor agonist that modulates appetite . Cardiovascular safety in obese/overweight patients was reported by Bohula et al. (2018) .
Clinical formulations contain lorcaserin hydrochloride (PubChem CID 11673085). (GtoPdb)
Compound Sets
19
BiasDB
Lorcaserin
Cayman Chemical Bioactives
15521
19247
42461
ChEMBL Approved Drugs
CHEMBL2095211
CHEMBL360328
ChEMBL Drugs
CHEMBL2095211
CHEMBL360328
Concise Guide to Pharmacology 2017/18
2941
Concise Guide to Pharmacology 2019/20
2941
Concise Guide to Pharmacology 2021/22
2941
Concise Guide to Pharmacology 2023/24
2941
CZ-OPENSCREEN Bioactive Library
DrugBank
DB04871
DrugBank Approved Drugs
DB04871
DrugCentral
4374
DrugCentral Approved Drugs
4374
DrugMAP
DMG6OYJ
DrugMAP Approved Drugs
DMG6OYJ
Guide to Pharmacology
2941
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL360328
Other bioactive compounds
ReFrame library
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
195.08
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
2.59
TPSA
12.03
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
7.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
5-HT Receptor agonist
Source data