General
Preferred name
MILNACIPRAN
Synonyms
(1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide ()
levomilnacipran ()
Milnacipran HCl ()
Savella ()
Dalcipran ()
MILNACIPRAN HYDROCHLORIDE ()
Dextromilnacipran ()
Milnacipran (hydrochloride) ()
(1R,2S)-milnacipran ()
F2696 ()
1R,2S-MILNACIPRAN HYDROCHLORIDE ()
Milnacipran ()
1R,2S-MILNACIPRAN ()
Milnacipran-d5 (hydrochloride) ()
P&D ID
PD009351
CAS
86181-08-0
105310-09-6
92623-85-3
101152-94-7
96847-55-1
Tags
available
drug
Drug indication
Depression
Drug Status
approved
withdrawn
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for fibromyalgia.
PRICE 29
DESCRIPTION Dextromilnacipran (F2696; (1R,2S)-milnacipran), an enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Dextromilnacipran also is a human alpha-adrenergic receptor antagonist, with an IC50 of 3.4 ¦ÌM. (patent WO2013014263A1).
PRICE 37
DESCRIPTION Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice. (TargetMol Bioactive Compound Library)
DESCRIPTION Dextromilnacipran (Levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor. (TargetMol Bioactive Compound Library)
Compound Sets
14
Cayman Chemical Bioactives
23837
31981
DrugMAP
DMBFE74
DrugMAP Approved Drugs
DMBFE74
EU-OPENSCREEN Bioactive Compound Library
EOS101255
MedChem Express Bioactive Compound Library
HY-B0168A
HY-14794
NCATS Inxight Approved Drugs
G56VK1HF36
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
milnacipran-hydrochloride
TargetMol Bioactive Compound Library
T1189
T2594
Withdrawn 2.0
EMA27
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
246.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
1.77
TPSA
46.33
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
6.0
QED
0.86
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
5-HT Reuptake Inhibitors
Norepinephrine Reuptake Inhibitors
ATC
N06AX17
Pathway
Neuroscience
Neuronal Signaling
Cell Cycle/DNA Damage
Target
Serotonin Transporter
PERK
5-HR-norepinephrine reuptake
norepinephrine transporter (NET)
norepinephrine transporter (SERT)
Therapeutic Class
Antidepressants
Source data