General
Preferred name
TAMIBAROTENE
Synonyms
CHEMBL25202 ()
Am 80 ()
Amnolake ()
NSC 608000 ()
PMID27336223-Compound-4 ()
RR-110 ()
AM80 ()
TOS-80T ()
Amnoid ()
OP-01 ()
Sy-1425 ()
TM-411 ()
INNO-507 ()
NSC-608000 ()
AM-80 ()
P&D ID
PD009345
CAS
94497-51-5
Tags
available
probe
drug
Approved by
PMDA
First approval
2005
Drug indication
T-cell leukaemia
Alzheimer disease
Drug Status
investigational
approved
Max Phase
Phase 3
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
5
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This compound is a retinoic acid receptor α (RARα) agonist .
(GtoPdb)
DESCRIPTION
Selective RXR modulator
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
6
Organisms
0
Compound Sets
24
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tool Compound Set
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
351.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.99
TPSA
66.4
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Retinoic acid receptor alpha
RAR??
RARA, RARB
RAR/RXR
Retinoid Receptor
Pathway
Metabolism
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Primary Target
Retinoic Acid Receptors
MOA
Agonist
Retinoid Receptor agonist
Indication
acute promyelocytic leukemia (APL)
Source data
