General
Preferred name
PRASUGREL
Synonyms
CS-747 ()
Prasugrel (Maleic acid) ()
PCR 4099 (Maleic acid) ()
LY640315 ()
PCR 4099 ()
Prasugrel HCl ()
Effient ()
PCR 4099 (hydrochloride) ()
LY 640315 Hydrochloride ()
Prasugrel (Effient) ()
PRASUGREL HYDROCHLORIDE ()
Prasugrel (hydrochloride) ()
Effient, Efient, Prasita,CS-747, LY640315,PCR 4099 ()
Prasugrel HCl, LY640315,PCR 4099 Hydrochloride ()
PRASUGREL BESYLATE ()
NSC-759625 ()
Efient ()
LY-640315 ()
Prasu doc ()
Prasugrel-d5 ()
Prasugrel viatris (previously prasugrel mylan) ()
P&D ID
PD009320
CAS
150322-43-3
389574-19-0
1127252-92-9
Tags
available
prodrug
drug
Approved by
FDA
PMDA
EMA
First approval
2018
2009
Drug indication
Recurrent thrombophlebitis
Acute coronary syndrome
Myocardial infarction
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Prasugrel is a thienopyridine ADP receptor inhibitors which inhibits platelet aggregation by irreversibly binding to P2Y12 receptors.
METABOLISM Prasugrel is not detected in plasma following oral administration. It is rapidly hydrolyzed in the intestine to thiolactone by human carboxylesterase (hCE) 2. This intermediate is further metabolized to its active metabolite, R-138727, in a single step by cytochrome P450 enzymes in the liver (primarily CYP3A4 and CYP2B6 and to a lesser extent by CYP2C9 and CYP2C19). The active metabolite is further metabolized by S-methylation or cysteine conjugation to two inactive metabolites.; ; Unlike clopidogrel, transformation of prasugrel to its active metabolite does not appear to be affected by cytochrome P450 polymorphisms.
DESCRIPTION This drug is metabolised to its active metabolite R-138727.
Marketed formulations may contain prasugrel hydrochloride (PubChem CID 10158453). (GtoPdb)
PRICE 29
DESCRIPTION Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].
PRICE 29
DESCRIPTION Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and proagent, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].
DESCRIPTION Potent and selective GPR39 agonist; orally bioavailable (Tocris Bioactive Compound Library)
DESCRIPTION Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those undergoing PERCUTANEOUS CORONARY INTERVENTIONS. (TargetMol Bioactive Compound Library)
DESCRIPTION Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome. (TargetMol Bioactive Compound Library)
Compound Sets
21
AdooQ Bioactive Compound Library
A10748
Cayman Chemical Bioactives
14278
28160
ChEMBL Approved Drugs
CHEMBL1201772
CHEMBL1201773
CHEMBL6068340
ChEMBL Drugs
CHEMBL1201772
CHEMBL1201773
CHEMBL6068340
CZ-OPENSCREEN Bioactive Library
DrugBank
DB06209
DrugBank Approved Drugs
DB06209
DrugCentral
4113
DrugCentral Approved Drugs
4113
DrugMAP
DM7MT6E
DrugMAP Approved Drugs
DM7MT6E
DrugMatrix
Guide to Pharmacology
7562
JUMP-Target 1 Compound Set
6918456
MedChem Express Bioactive Compound Library
HY-15284
HY-15284A
NCATS Inxight Approved Drugs
34K66TBT99
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Prasugrel
prasugrel-hydrochloride
TargetMol Bioactive Compound Library
T0230
T6952
Tocris Bioactive Compound Library
6317
External IDs
68
Properties
(calculated by RDKit )
Molecular Weight
373.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
3.89
TPSA
46.61
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
P2Y Receptor
P2Y
P2Y12
P2RY12
P2 Receptor
Pathway
GPCR/G protein
Neuroscience
Primary Target
Purinergic (P2Y) Receptors
MOA
Antagonist
Source data