General
Preferred name
LACOSAMIDE
Synonyms
Erlosamide ()
SPM927 ()
ADD243037 ()
SPM-927 ()
Motpoly ()
Lacosamide adroiq ()
Lacosamide ucb ()
ADD-243037 ()
ERLOSAMIDE ()
ADD 243037 ()
(r)-lacosamide 1 ()
Lacosamide accord ()
Motpoly xr ()
Vimpat ()
SPM 927 ()
Lacosamida ()
Lacosamide cv ()
Lacosamide ()
Lacosamide-d3 ()
P&D ID
PD009314
CAS
175481-36-4
175481-26-2
1217689-95-6
Tags
available
drug
Approved by
FDA
PMDA
EMA
First approval
2008
Drug indication
Convulsion
Epilepsy
Diabetic neuropathy
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Lacosamide is a functionalized amino acid anticonvulsant drug .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
Axon Medchem Screening Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
250.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
0.45
TPSA
67.43
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
voltage-gated sodium channel blocker
NMDA Glycine-Site Antagonists
Sodium Channel Blockers
Target
Sodium channel alpha subunit
Na+ channel blocker
Member status
virtual
Therapeutic Class
Analgesics
VGSC Target
Nav1.5
Nav1.7
Nav1.8
Source data
