General
Preferred name
LACOSAMIDE
Synonyms
Erlosamide ()
ERLOSAMIDE ()
Lacosamide ()
Lacosamide cv ()
ADD 243037 ()
ADD-243037 ()
Vimpat ()
(r)-lacosamide 1 ()
SPM 927 ()
SPM-927 ()
Lacosamide-d3 ()
P&D ID
PD009314
CAS
175481-36-4
175481-26-2
1217689-95-6
Tags
natural product
drug
available
Approved by
PMDA
EMA
FDA
First approval
2008
Drug Status
approved
Drug indication
Convulsion
Diabetic neuropathy
Epilepsy
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lacosamide is a functionalized amino acid anticonvulsant drug . (GtoPdb)
Compound Sets
22
Axon Medchem Screening Library
1444
Cayman Chemical Bioactives
10012592
25426
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL58323
ChEMBL Drugs
CHEMBL58323
Concise Guide to Pharmacology 2017/18
7472
Concise Guide to Pharmacology 2019/20
7472
Concise Guide to Pharmacology 2021/22
7472
Concise Guide to Pharmacology 2023/24
7472
DrugBank
DB06218
DrugBank Approved Drugs
DB06218
DrugCentral
4310
DrugCentral Approved Drugs
4310
DrugMAP
DMVM6QR
DrugMAP Approved Drugs
DMVM6QR
Guide to Pharmacology
7472
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL58323
NCATS Inxight Approved Drugs
563KS2PQY5
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
VGSC-DB
NA0125
NA0126
NA0127
External IDs
39
Properties
(calculated by RDKit )
Molecular Weight
250.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
0.45
TPSA
67.43
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
voltage-gated sodium channel blocker
NMDA Glycine-Site Antagonists
Sodium Channel Blockers
Target
Sodium channel alpha subunit
Na+ channel blocker
Member status
virtual
Therapeutic Class
Analgesics
VGSC Target
Nav1.5
Nav1.7
Nav1.8
Source data