General
Preferred name
PICROTOXININ
Synonyms
P&D ID
PD009304
CAS
17617-45-7
Tags
available
natural product
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Picrotoxinin is a plant-derived neurotoxic sesquiterpenoid compound.
(GtoPdb)
DESCRIPTION
Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits ¦Á1¦Â2¦Ã2L GABAA receptor with an IC50 of 1.15 ¦ÌM[1].
PRICE
33
DESCRIPTION
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 ??M for ??1??2??2L GABAA. Picrotoxinin shows convulsant properties.
DESCRIPTION
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Guide to Pharmacology
JUMP-Target 1 Compound Set
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
292.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
0
cLogP
-0.06
TPSA
85.36
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Chloride channel
GABAA
GLRA1, GLRA2, GLRA3, GLRB, HTR3A, HTR3B
GLRA3
GABA Receptor
MOA
GABA Receptor antagonist
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Source data
