General
Preferred name
BAZEDOXIFENE
Synonyms
BAZEDOXIFENE ACETATE ()
TSE424 hydrochloride ()
WAY 140424 hydrochloride ()
TSE-424 hydrochloride ()
TSE 424 hydrochloride ()
WAY-TES 424 ()
TSE 424 ()
WAY-140424 ()
Bazedoxifene hydrochloride ()
Bazedoxefene ()
Bazedoxifene (acetate)-B ()
Bazedoxifene (acetate)-D ()
Bazedoxifene (acetate) ()
TSE-424 (acetate)-B ()
TSE-424 (acetate)-D ()
TSE-424 ()
TSE-424 (acetate) ()
WAY-140424,TSE-424 acetate ()
Bazedoxifene (WAY-140424) HCl ()
Bazedoxifene (TSE-424) acetate ()
Bazedoxifene-d4 ()
Conbriza ()
Duavive ()
Bazedoxifen acetate ()
Bazedoxifene acetate component of duavee ()
BAZEDOXIFENO ()
Bazedoxifene component of ak r215 ()
Bazedoxifene component of ak-r215 ()
BAZEDOXIFENE COMPONENT OF AK R215 ()
BAZEDOXIFENE COMPONENT OF AK-R215 ()
P&D ID
PD009303
CAS
198481-32-2
198481-33-3
198480-56-7
1133695-49-4
Tags
available
drug
Approved by
FDA
First approval
2013
2009
Drug indication
Osteopetrosis
Osteoporosis
Postmenopausal osteoporosis
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ER¦Á and ER¦Â, respectively. Bazedoxifene acetate can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].
DESCRIPTION Bazedoxifene (acetate)-B (TSE-424 (acetate)-B) is the B-crystal form compound of Bazedoxifene acetate (HY-A0036). Bazedoxifene acetate is an orally active, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ER¦Á and ER¦Â, respectively[1].
DESCRIPTION Bazedoxifene (acetate)-D (TSE-424 (acetate)-D) is the D-crystal form compound of Bazedoxifene acetate (HY-A0036). Bazedoxifene acetate is an orally active, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ER¦Á and ER¦Â, respectively[1].
PRICE 56
PRICE 253
DESCRIPTION Bazedoxifene hydrochloride (TSE 424 hydrochloride) is an orally active, selective, and potent estrogen receptor modulator (SERM) that crosses the blood-brain barrier and is an inhibitor of IL-6/GP130 protein interactions with high affinity for ER?? and ER??. It has a high affinity for ER?? and ER?? and can be used to study postmenopausal osteoporosis and vasodilator-related diseases.
INDICATION Indicated for following conditions alone or in combination with conjugated estrogens in women with a uterus:; ; - Treatment of moderate to severe vasomotor symptoms associated with menopause; ; - Prevention of postmenopausal osteoporosis
DESCRIPTION Bazedoxifene is a selective estrogen receptor modulator (SERM). (GtoPdb)
DESCRIPTION Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ER¦Á and ER¦Â, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].
DESCRIPTION Highly potent and muscle-selective androgen receptor (AR) agonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent and selective estrogen receptor modulator (SERM) (Tocriscreen Plus)
DESCRIPTION Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM). (TargetMol Bioactive Compound Library)
DESCRIPTION Bazedoxifene hydrochloride (TSE 424 hydrochloride) is an orally active, selective, and potent estrogen receptor modulator (SERM) that crosses the blood-brain barrier and is an inhibitor of IL-6/GP130 protein interactions with high affinity for ERα and ERβ. It has a high affinity for ERα and ERβ and can be used to study postmenopausal osteoporosis and vasodilator-related diseases. (TargetMol Bioactive Compound Library)
DESCRIPTION Bazedoxifene is an indole derivative and third-generation selective estrogen receptor modulator (SERM) with potential antineoplastic activity. It is used to treat moderate to severe vasomotor symptoms in menopause and osteoporosis alone or in combination with conjugated estrogens. (Enamine Bioactive Compounds)
Cell lines
6
Organisms
3
Compound Sets
30
AdooQ Bioactive Compound Library
A11665
Axon Medchem Screening Library
2051
1748
Cayman Chemical Bioactives
15005
22554
ChEMBL Approved Drugs
CHEMBL2106615
CHEMBL46740
ChEMBL Drugs
CHEMBL2106615
CHEMBL46740
Concise Guide to Pharmacology 2017/18
7355
Concise Guide to Pharmacology 2019/20
7355
Concise Guide to Pharmacology 2021/22
7355
Concise Guide to Pharmacology 2023/24
7355
Drug Repurposing Hub
DrugBank
DB06401
DrugBank Approved Drugs
DB06401
DrugCentral
4334
DrugCentral Approved Drugs
4334
DrugMAP
DMY85QW
DrugMAP Approved Drugs
DMY85QW
Enamine Bioactive Compounds
EBC-27177
EUbOPEN Chemogenomics Library
EUB0000584
Guide to Pharmacology
7355
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL46740
MedChem Express Bioactive Compound Library
HY-A0036
HY-A0036B
HY-A0036D
HY-A0031
NCATS Inxight Approved Drugs
Q16TT9C5BK
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F78CD2792E0
ReFrame library
Selleckchem Bioactive Compound Library
Bazedoxifene-acetate
bazedoxifene-hcl
TargetMol Bioactive Compound Library
T2544
T6404
The Spectrum Collection
Tocris Bioactive Compound Library
5263
Tocriscreen Plus
5263
External IDs
72
Properties
(calculated by RDKit )
Molecular Weight
470.26
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
6.33
TPSA
57.86
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
7.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Target
SERM
gp130
IL-6
ERα
ERβ
Estrogen Receptor/ERR
ER¦Á
ER¦Â
ESR1, ESR2
Estrogen/progestogen Receptor
Primary Target
Estrogen and Related Receptors
MOA
Estrogen/progestogen Receptor inhibitor
Modulator
Selective Estrogen Receptor Modulator (SERM)
Indication
osteoporosis, menopause
Disease Area
orthopedics, endocrinology
Pathway
Endocrinology/Hormones
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Recommended Cell Concentration
None
Source data