General
Preferred name
BAZEDOXIFENE
Synonyms
BAZEDOXIFENE ACETATE ()
WAY-TES 424 ()
TSE 424 ()
WAY-140424 ()
Bazedoxifene hydrochloride ()
Bazedoxifene (acetate) ()
Bazedoxefene ()
TSE-424 ()
TSE-424 (acetate) ()
Bazedoxifene (WAY-140424) HCl ()
Bazedoxifene (TSE-424) acetate ()
WAY-140424,TSE-424 acetate ()
Bazedoxifen acetate ()
Conbriza ()
Duavive ()
Bazedoxifene-d4 ()
P&D ID
PD009303
CAS
198481-32-2
198481-33-3
198480-56-7
1133695-49-4
Tags
available
drug
Approved by
FDA
First approval
2013
2009
Drug Status
investigational
approved
Drug indication
Osteopetrosis
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Indicated for following conditions alone or in combination with conjugated estrogens in women with a uterus:; ; - Treatment of moderate to severe vasomotor symptoms associated with menopause; ; - Prevention of postmenopausal osteoporosis
DESCRIPTION Bazedoxifene is a selective estrogen receptor modulator (SERM). (GtoPdb)
DESCRIPTION Highly potent and muscle-selective androgen receptor (AR) agonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent and selective estrogen receptor modulator (SERM) (Tocriscreen Plus)
Cell lines
2
Organisms
3
Compound Sets
28
AdooQ Bioactive Compound Library
A11665
Axon Medchem Screening Library
2051
1748
Cayman Chemical Bioactives
15005
22554
ChEMBL Approved Drugs
CHEMBL2106615
CHEMBL46740
ChEMBL Drugs
CHEMBL2106615
CHEMBL46740
Concise Guide to Pharmacology 2017/18
7355
Concise Guide to Pharmacology 2019/20
7355
Concise Guide to Pharmacology 2021/22
7355
Concise Guide to Pharmacology 2023/24
7355
Drug Repurposing Hub
DrugBank
DB06401
DrugBank Approved Drugs
DB06401
DrugCentral
4334
DrugCentral Approved Drugs
4334
DrugMAP
DMY85QW
DrugMAP Approved Drugs
DMY85QW
Guide to Pharmacology
7355
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL46740
MedChem Express Bioactive Compound Library
HY-A0036
HY-A0031
NCATS Inxight Approved Drugs
Q16TT9C5BK
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F78CD2792E0
ReFrame library
Selleckchem Bioactive Compound Library
Bazedoxifene-acetate
bazedoxifene-hcl
TargetMol Bioactive Compound Library
T2544
The Spectrum Collection
Tocris Bioactive Compound Library
5263
Tocriscreen Plus
5263
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
470.26
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
6.33
TPSA
57.86
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
7.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Pathway
Endocrinology/Hormones
Vitamin D Related/Nuclear Receptor
Target
ER??
ER¦Á
ER¦Â
ESR1, ESR2
SERM
Estrogen Receptor/ERR
Estrogen/progestogen Receptor
Primary Target
Estrogen and Related Receptors
MOA
Estrogen/progestogen Receptor inhibitor
Modulator
Selective Estrogen Receptor Modulator (SERM)
Indication
osteoporosis, menopause
Disease Area
orthopedics, endocrinology
Source data