General
Preferred name
XYLOMETAZOLINE
Synonyms
XYLOMETAZOLINE HYDROCHLORIDE ()
Xylometazoline HCl ()
xylometazoline, Novartis ()
Xylometazoline (hydrochloride) ()
Ba-11391, otrivine, rhinoxilin ()
Neo-synephrine ii ()
Xylomet HCl ()
Nazo-Mist ()
Otrivine Hay Fever For ()
Otraspray ()
Otrivine ()
Otradrops ()
Otrivin hydrochloride ()
NSC-757378 ()
Balminil ()
Xilometazolina ()
P&D ID
PD009290
CAS
1218-35-5
526-36-3
Tags
available
drug
Approved by
FDA
Drug indication
Allergic rhinitis
eye allergy
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Xylometazoline hydrochloride is an ¦Á-adrenergic receptor agonist (Ki=0.05-1.7 ¦ÌM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2][3][4].
DESCRIPTION Xylometazoline hydrochloride (Xylometazoline HCl) is an ??-adrenoceptor agonist usually used as nasal decongestant.
DESCRIPTION Marketed formulations contain xylometazoline hydrochloride (PubChem CID 5282386). (GtoPdb)
DESCRIPTION Xylometazoline is an imidazoline derivative with sympathomimetic and nasal decongestant activity. It works by binding to alpha (α)-adrenergic receptors to cause vasoconstriction of nasal blood vessels. Xylometazoline is indicated for the temporary relief of nasal congestion due to cold, hay fever or other respiratory allergies. (Enamine Bioactive Compounds)
DESCRIPTION alpha-Adrenoceptor agonist; imidazoline binding site ligand (LOPAC library)
DESCRIPTION Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. (BOC Sciences Bioactive Compounds)
DESCRIPTION Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
28
BOC Sciences Bioactive Compounds
xylometazoline-hcl-cas-1218-35-5-item-84-55846
Cayman Chemical Bioactives
27797
ChEMBL Approved Drugs
CHEMBL1256400
CHEMBL312448
ChEMBL Drugs
CHEMBL1256400
CHEMBL312448
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06694
DrugBank Approved Drugs
DB06694
DrugCentral
3658
DrugCentral Approved Drugs
3658
DrugMAP
DMKV32D
DrugMatrix
Enamine Bioactive Compounds
EBC-04431
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101791
Guide to Pharmacology
517
Ki Database
Xylometazoline
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL312448
MedChem Express Bioactive Compound Library
HY-B0475
NCATS Inxight Approved Drugs
WPY40FTH8K
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
xylometazoline-hcl
xylometazoline
TargetMol Bioactive Compound Library
T0042
The Spectrum Collection
External IDs
89
Properties
(calculated by RDKit )
Molecular Weight
244.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
3.15
TPSA
24.39
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha
Target
Adrenergic Receptor
α1A-adrenergic receptor
α1B-adrenergic receptor
α1D-adrenergic receptor
α2A-adrenergic receptor
α2B-adrenergic receptor
α2C-adrenergic receptor
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C
Member status
virtual
MOA
alpha2A(2D)-Adrenoceptor Agonists
alpha2B-Adrenoceptor Agonists
alpha2C-Adrenoceptor Agonists
Adrenergic Receptor agonist
Disease Area
otolaryngology, allergy
Indication
nasal congestion, allergic rhinitis
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data