General
Preferred name
IOBENGUANE
Synonyms
Iobenguane Sulfate (131I) ()
M131Ibg ()
Iobenguane sulfate i 123 ()
m-Iodobenzylguanidine hemisulfate ()
MIBG-I-123 ()
Iobenguane Sulfate (123I) ()
Adreview ()
Iodobenzylguanidine Sulfate (123I) ()
Iobenguane sulfate i-123 ()
IOBENGUANE[131I] ()
iobenguane (123I) ()
iobenguane (131I) ()
Iobenguane sulfate ()
IOBENGUANE I-131 ()
IOBENGUANE I-123 ()
Iobenguane sulfate I-123 ()
Metaiodobenzylguanidine I-131 ()
Iobenguane (sulfate) ()
IOBENGUANE I 123 ()
IOBENGUANE I 131 ()
IOBENGUANE SULFATE I 131 ()
MIBG (sulfate) ()
Iobenguane (127-i) ()
Iobenguane, i-131 ()
Iobenguane (131 i) ()
Azedra ()
Mibg i-131 ()
(131i)-mibg ()
131i-mibg ()
3-iodobenzylguanidine, i-131 ()
131 i-mibg ()
Iodine (131i) iobenguane ()
I-131 metaiodobenzylguanidine ()
3-iodobenzylguanidine (131i) ()
Iobenguane (123-i) ()
Metaiodobenzylguanidine i-123 ()
Mibg i-123 ()
123i-mibg ()
Iobenguane (123 i) ()
3-iodobenzylguanidine (123i) ()
Iodine (123i) iobenguane ()
Andreview ()
123i-metaiodobenzylguanidine ()
Iobenguane i-123 hemisulfate ()
Iobenguane i 123 hemisulfate ()
Iobenguane sulphate i 123 ()
Iodobenzylguanidine sulfate i 123 ()
Iobenguane, i-123 hemisulphate ()
Iobenguane i-123 hemisulphate ()
Iobenguane i 123 hemisulphate ()
Iobenguane sulphate i-123 ()
Iobenguane, i-123 hemisulfate ()
Iobenguane sulphate i 131 ()
Iobenguane sulphate i-131 ()
Iobenguane sulfate i-131 ()
m-Iodobenzylguanidine (hemisulfate) ()
P&D ID
PD009281
CAS
87862-25-7
80663-95-2
81241-79-4
139755-80-9
77679-27-7
76924-93-1
Tags
natural product
drug
available
Approved by
PMDA
FDA
First approval
2008
1994
2018
Drug Status
investigational
approved
Drug indication
Diagnostic Aid
Neuroendocrine cancer
Neuroblastoma
Pheochromocytoma
Radioactive Agent
Diagnostic Aid (radioactive, adrenomedullary disorders and neuroendocrine tumors)
Radioactive Agent,Radioactive Agent,Radioactive Agent
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE Renally excreted unchanged (70%-90%) via glomerular filtration;; Fecal (<1%)
TOXICITY Oral mouse: LD50 = 300 mg/kg;; Oral, rabbit: LD50 = 3200 mg/kg;; Oral, rat: LD50=980 mg/kg.; The most common adverse reactions, dizziness, rash, pruritis, flushing, headache, and injection site hemorrhage occurred in < 1.3% of patients.
DESCRIPTION Antitumor agent which inhibits ADP ribosylation; induces changes in the mitochondrial membrane potential, activation of caspase-3 and DNA fragmentation (LOPAC library)
DESCRIPTION Iobenguane I 131 is a guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
19
BOC Sciences Bioactive Compounds
iobenguane-cas-77679-27-7-item-84-465312
Cayman Chemical Bioactives
19998
ChEMBL Approved Drugs
CHEMBL818
CHEMBL1615779
CHEMBL3989523
CHEMBL3989511
ChEMBL Drugs
CHEMBL818
CHEMBL1615779
CHEMBL1615777
CHEMBL3989523
CHEMBL3989511
Drug Repurposing Hub
DrugBank
DB06704
DB09546
DrugBank Approved Drugs
DB06704
DB09546
DrugCentral
4577
1448
DrugCentral Approved Drugs
4577
1448
DrugMAP
DMNST69
DM80OEZ
DrugMAP Approved Drugs
DM80OEZ
DrugMatrix
LOPAC library
MedChem Express Bioactive Compound Library
HY-129040A
NCATS Inxight Approved Drugs
P2TH1XYZ84
Q461L7AK4R
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
External IDs
108
Properties
(calculated by RDKit )
Molecular Weight
274.99
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.27
TPSA
61.9
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
neuroblastoma, congestive heart failure, pheochromocytoma
Disease Area
oncology, cardiology, endocrinology
MOA
antineoplastic agent
Source data