General
Preferred name
ramosetron
Synonyms
YM-060 ()
YM 060 ()
YM060 ()
RAMOSETRON HYDROCHLORIDE ()
[3H]ramosetron ()
Ramosetron (Hydrochloride) ()
ramosetron (ODT) ()
Irribow ()
(r)-(-)-ramosetron hydrochloride ()
[3H]ramosetron ()
P&D ID
PD009272
CAS
132907-72-3
132036-88-5
Tags
available
drug candidate
drug
Approved by
PMDA
First approval
1996
Drug indication
Irritable bowel syndrome
Nausea and vomiting
Discovery agent
Drug Status
investigational
approved
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The hydrochloride salt form of Ramosetron, a benzimidazol derivative, could be used to against nausea and vomiting for acting as a 5-HT3 receptor antagonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
53
Molecular Weight
279.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
3
cLogP
2.89
TPSA
50.68
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT3
HTR3A
MOA
5-HT Receptor
serotonin receptor antagonist
Indication
nausea, vomiting, irritable bowel syndrome
Solubility
DMSO:≥ 22 mg/mL, H2O: 20 mg/mL
Source data
