General
Preferred name
SULBACTAM
Synonyms
CP-45899-2 ()
SULBACTAM SODIUM ()
Sulperazone-sulbactam sodium ()
Sulbactam (sodium) ()
CP45899 ()
CP45899 (sodium) ()
Unasyn, CP-45899-2 ()
SULBACTAM BENZATHINE ()
CP-458992 ()
NSC-759886 ()
Sulbactam sodium component of sulperazone ()
Sulbactam sodium component of unasyn ()
Sulbactam (as sodium) ()
CP-45,899-2 ()
Sulbactam sodium component of xacduro ()
Sulbactam sodium salt ()
CP-45899-99 ()
CP-45,899-99 ()
Sulbactum ()
P&D ID
PD009253
CAS
68373-14-8
69388-84-7
Tags
covalent binder
nuisance
drug
drug candidate
available
Approved by
FDA
First approval
1986
Drug Status
approved
Max Phase
4.0
Drug indication
infection
Bacterial pneumonia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Sulbactam is currently available in combination products with ampicillin. Within this formulation it is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below.; Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli, Klebsiella spp. (including K. pneumoniae), Proteus mirabilis, Bacteroides fragilis, Enterobacter spp., and Acinetobacter calcoaceticus.; Intra-Abdominal Infections caused by beta-lactamase producing strains of Escherichia coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp.; Gynecological Infections caused by beta-lactamase producing strains of Escherichia coli, and Bacteroides spp. (including B. fragilis).
DESCRIPTION Sulbactam is a β-lactamase inhibitor that is used to limit degradation of β-lactam antibacterials. Its synergy with β-lactam antibacterials against some multiply drug-resistant Enterobacteriaceae and Pseudomonas species is reported to be inconsistent, likely as it cannot inhibit the AmpC cephalosporinase expressed by these species . (GtoPdb)
DESCRIPTION Sulbactam (CP45899) is a competitive, irreversible beta-lactamase inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2].
DESCRIPTION Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2].
PRICE 29
DESCRIPTION Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible ??-lactamase inhibitor.
DESCRIPTION Sulbactam is a beta-lactamase inhibitor. It has a wide range of antibacterial activity that includes Gram-positive and Gram-negative aerobic and anaerobic bacteria. It is an antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections. (Enamine Bioactive Compounds)
DESCRIPTION Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
28
AdooQ Bioactive Compound Library
A11648
Axon Medchem Screening Library
2041
Cayman Chemical Bioactives
15024
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL403
CHEMBL1200944
ChEMBL Drugs
CHEMBL403
CHEMBL1200944
CHEMBL3989650
CovalentInDB
CI000079
CovBinderInPDB
CBR000176
CBR000241
CBR000242
CBR001862
CBR002514
CBR002515
CBR007265
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB09324
DrugBank Approved Drugs
DB09324
DrugCentral
2492
DrugCentral Approved Drugs
2492
Enamine Bioactive Compounds
EBC-07481
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100805
Guide to Pharmacology
10769
MedChem Express Bioactive Compound Library
HY-B0334
HY-B0334A
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
S4TF6I2330
NPC Screening Collection
Nuisance compounds in cellular assays
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
sulbactam
sulbactam-sodium-unasyn
TargetMol Bioactive Compound Library
T6685
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
233.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
0
cLogP
-0.79
TPSA
91.75
Fraction CSP3
0.75
Chiral centers
2.0
Largest ring
5.0
QED
0.6
Structural alerts
1
Beta lactamase inhibition
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
MOA
bacterial beta-lactamase inhibitor
beta lactamase inhibitor
Target
Bacterial beta-lactamase TEM
antibiotic
Bacterial
β-Lactamase
ß-lactamase inhibitor
¦Â-Lactamase
Indication
skin infections, intra-abdominal infections, gynecologic infections
Biosynthetic Origin
Peptide (beta-Lactam)
Therapeutic Indication
b-Lactamase Inhibitor
Therapeutic Class
Antimicrobial
Pathway
Microbiology/virology
Anti-infection
Source data