General
Preferred name
FOSPROPOFOL
Synonyms
FOSPROPOFOL DISODIUM ()
Fospropofol sodium ()
Fospropofol disodium salt ()
Aquavan ()
Lusedra ()
P&D ID
PD009247
CAS
258516-87-9
258516-89-1
Tags
prodrug
drug
Approved by
FDA
First approval
2008
Drug Status
illicit
investigational
approved
Drug indication
Monitored anaesthesia care
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fospropofol is a prodrug which undergoes hepatic conversion to the active moeity, propofol.
(GtoPdb)
HALF-LIFE
When given to a patient, the half-lives are as follows: ; Fospropofol = 0.81 hours; ; Propofol metabolite = 1.13 hours ;
ABSORPTION
Adequate sedation achieved after 7 minutes with a IV bolus dose of 10mg/kg. It takes 21-45 minutes for patients to recover for fospropopol-induced sedation. Following an intravenous bolus administration of 6 mg/kg in a healthy subject, the pharmacokinetic parameters of fospropofol are as follows: ; Cmax = 78.7 μg/mL;; Tmax = 4 minutes; ; AUC(0-â) = 19.0 μg â
h/mL; ;
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
NCATS Inxight Approved Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
288.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
3.38
TPSA
75.99
Fraction CSP3
0.54
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
