General
Preferred name
CALCIUM CARBONATE
Synonyms
Marble ()
Aeromatt ()
Calcii carbonas ()
Hydrolyzed pearl ()
Calcium (as carbonate) ()
Citrical ()
Remegel ()
Glauberitum ()
Calcidrink ()
E170 ()
Calcite ()
Rennie Gold ()
Phx cal-carb buffer ()
Calcette ()
Limestone, ground ()
Chalk, Precipitated ()
Calcitum ()
Cal-Sup ()
Precipitated Calcium Carbonate ()
Adcal ()
Children's Mylanta Upset Stomach Relief ()
Calcichew Fte ()
E-170(I) ()
INS NO.170(I) ()
Cacit ()
Calc 500 ()
Ci 77220 ()
Purecal ()
Chooz ()
Calcium (as calcium carbonate) ()
Chalk ()
Calcichew ()
Limestone ()
Marble dust ()
INS-170(I) ()
Mylanta Soothing Lozenges ()
Os-Cal ()
Setlers ()
Titralac ()
Precpitated calcium carbonate ()
Calcite (ca(co3)) ()
Han shui shi ()
Rennie Fruit ()
NDI 443 ()
Rennie ()
Tums ()
Albacar ()
P&D ID
PD009243
CAS
308068-21-5
13397-26-7
114453-69-9
13397-25-6
471-34-1
1317-65-3
Tags
available
drug
Drug Status
investigational
approved
Max Phase
Phase 4
Drug indication
Antacid
First approval
2000
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. ; When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.
MOA Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).;
Compound Sets
4
ChEMBL Approved Drugs
CHEMBL1200539
ChEMBL Drugs
CHEMBL1200539
DrugBank
DB06724
DrugBank Approved Drugs
DB06724
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
99.95
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-2.83
TPSA
63.19
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.31
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data