General
Preferred name
KETOBEMIDONE
Synonyms
IDS-NK-001(SECT.3) ()
Cetobemidone ()
Ketogan ()
NSC-117863 ()
Ketodur ()
A 21 lundbeck ()
Ciba 7115 ()
Cliradone ()
Cetobemidona ()
Ketorax ()
IDS-NK-001 ()
Cymidon ()
P&D ID
PD009240
CAS
469-79-4
Tags
available
drug
First approval
1947
Drug indication
Pain
Drug Status
approved
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Ketobemidone (Cliradon, Ketogan, Ketodur, Cymidon, Ketorax, &c.) is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hydrochloride or sulfate and circa 8 mg of ketobemidone by injection.
HALF-LIFE Plasma half-life: 2.42 +/- 0.41 h (m +/- SD).; Elimination half-life: 3.27 +/- 0.32 h
TOXICITY Base: Rat Intravenous LD50: 10 mg/kg; Mouse Intravenous LD50: 14 mg/kg.; Hydrochloride salt: Rat Oral LD50: 215 mg/kg; Rat Intravenous LD50: 40 mg/kg;
Compound Sets
8
ChEMBL Drugs
CHEMBL47072
DrugBank
DB06738
DrugCentral
1526
DrugCentral Approved Drugs
1526
DrugMAP
DMM3L6Z
DrugMAP Approved Drugs
DMM3L6Z
DrugMatrix
ReFrame library
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
247.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
2.33
TPSA
40.54
Fraction CSP3
0.53
Chiral centers
0.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data