General
Preferred name
METHYLNALTREXONE
Synonyms
MOA-728 ()
MOA 728 ()
MOA728 ()
Relistor ()
METHYLNALTREXONE BROMIDE ()
Methylnaltrexone D3 (Bromide) ()
Methylnaltrexone (Bromide) ()
MRZ-2663 ()
Methylnaltrexone cation ()
Methylnaltrexone ion ()
MRZ-2663BR ()
Naltrexone methylbromide ()
MRZ 2663BR ()
N-methylnaltrexone bromide ()
Naltrexone methobromide ()
P&D ID
PD009221
CAS
73232-52-7
83387-25-1
Tags
available
drug
Approved by
EMA
FDA
First approval
2008
Drug indication
Opioid-induced constipation
Obesity
Drug Status
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The charged tetravalent nitrogen atom in this molecule reduces its ability to cross the blood-brain barrier, thereby restricting its activity to peripheral targets. This type of peripherally acting mu-opioid receptor antagonist is known by the acronym PAMORA.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
Natural product-based probes and drugs
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
356.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
1
cLogP
1.67
TPSA
66.76
Fraction CSP3
0.67
Chiral centers
5.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??-opioid receptor
Opioid Receptor
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Constipation
Therapeutic Class
CNS & PNS
Source data
