General
Preferred name
SULCONAZOLE
Synonyms
SULCONAZOLE NITRATE ()
(¡À)-Sulconazole nitrat ()
Exelderm ()
RS 44872 ()
(??)-Sulconazole nitrat ()
(¡À)-Sulconazole (nitrate) ()
Sulconazole (nitrate) ()
Sulconazole (mononitrate) ()
(±)-Sulconazole (mononitrate) ()
Exelderm,RS 44872 ()
Sulconazole mononitrate ()
RS-44872 ()
Myk ()
NSC-757849 ()
Sulcosyn ()
RS-44872-00-10-3 ()
RS-44872-00-1O-3 ()
Sulconazol ()
(¡À)-Sulconazole (mononitrate) ()
P&D ID
PD009216
CAS
61318-91-0
61318-90-9
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Tinea pedis
First approval
1985
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Sulconazole mononitrate ((¡À)-Sulconazole mononitrate), an imidazole derivative, is a broad-spectrum fungicide. Sulconazole mononitrate can be used for the research of dermatomycoses, pityriasis versicolor, and cutaneous candidiasis[1][2].
DESCRIPTION
Sulconazole mononitrate, a broad-spectrum antifungal medication of the imidazole class, can be used to study dermatomycoses, pityriasis versicolor and cutaneous candidiasis.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
18
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
396.0
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
6.52
TPSA
17.82
Fraction CSP3
0.17
Chiral centers
1.0
Largest ring
6.0
QED
0.47
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology/virology
Anti-infection
MOA
Antibiotic
Target
Fungal
Bacterial
antibiotic
Solubility
Soluble in Acetonitrile (Slightly, Heated), Methanol (Slightly), Water (Slightly)
Source data
