General
Preferred name
VIOMYCIN
Synonyms
VIOMYCIN SULFATE ()
Viomycin ()
Viomycin sulphate ()
NSC-760360 ()
Florimycin sulfate ()
Viocin Sulfate ()
Vioactane ()
Celiomycin ()
Florimycin ()
Vinacetin a ()
Tuberactinomycin b ()
Viomycin ()
P&D ID
PD009213
CAS
37883-00-4
32988-50-4
Tags
natural product
drug
available
Approved by
FDA
Drug Status
approved
withdrawn
Drug indication
Bacterial infection
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Viomycin binds to a site on the ribosome which lies at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit. The structures of this complexes suggest that the viomycin inhibits translocation by stabilizing the tRNA in the A site in the pretranslocation state. This inhibits protein synthesis.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
685.33
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
15
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
0
cLogP
-8.88
TPSA
392.86
Fraction CSP3
0.6
Chiral centers
7.0
Largest ring
16.0
QED
0.09
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
J
Source data
