General
Preferred name
VIOMYCIN
Synonyms
VIOMYCIN SULFATE ()
Viomycin ()
NSC-760360 ()
Florimycin sulfate ()
Viomycin sulphate ()
Viocin Sulfate ()
Celiomycin ()
Florimycin ()
Vioactane ()
Tuberactinomycin b ()
Vinacetin a ()
Viomycin ()
P&D ID
PD009213
CAS
37883-00-4
32988-50-4
Tags
drug
natural product
available
Approved by
FDA
Drug indication
Bacterial infection
Drug Status
withdrawn
approved
Max Phase
4.0
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Viomycin binds to a site on the ribosome which lies at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit. The structures of this complexes suggest that the viomycin inhibits translocation by stabilizing the tRNA in the A site in the pretranslocation state. This inhibits protein synthesis.
DESCRIPTION
Viomycin was the first member of the tuberactinomycin class of antimycobacterial compounds to be identified and was originally isolated from cultures of the actinomycete Streptomyces puniceus .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
NPC Screening Collection
Prestwick Chemical Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
685.33
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
15
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
0
cLogP
-8.88
TPSA
392.86
Fraction CSP3
0.6
Chiral centers
7.0
Largest ring
16.0
QED
0.09
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
J
Source data
