General
Preferred name
CHLOROPYRAMINE
Synonyms
CHLOROPYRAMINE HYDROCHLORIDE ()
Avapena ()
Halopyramine hydrochloride ()
Alergosan ()
Nilfan ()
Halopyramine ()
C4 ()
Chlorpyramin HCl ()
CHLORPYRAMIN HYDROCHLORIDE ()
NSC-241038 ()
P&D ID
PD009208
CAS
6170-42-9
59-32-5
10458-04-5
Tags
natural product
drug
available
Drug Status
experimental
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Chlorpyramine is a competitive reversible H1 receptor antagonist. This inhibits vasodilation, increases in vascular permeability, and tissue edema associated with histamine release. In addition, chloropyramine has some anticholinergic properties. These effects, along with its ability to pass through the blood-brain barrier lead to side effects such as drowsiness, weakness, vertigo, fatigue, dryness in the mouth, constipation, and rarely - visual disturbances and increase of intraocular pressure.
DESCRIPTION Halopyramine is known as a competitive reversible H1-receptor antagonist. It exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor. It inhibits the vasodilation, increased vascular permeability, and tissue edema associated with histamine release in the tissue by blocking the effects of histamine. It is a first generation antihistamine drug for the treatment of allergic rhinitis, allergic conjunctivitis, bronchial asthma, and other allergic conditions. It has been listed. (BOC Sciences Bioactive Compounds)
Cell lines
10
Organisms
0
Compound Sets
15
BOC Sciences Bioactive Compounds
halopyramine-cas-59-32-5-item-95172
ChEMBL Drugs
CHEMBL1194287
Drug Repurposing Hub
DrugBank
DB08800
DrugCentral
606
DrugCentral Approved Drugs
606
DrugMatrix
IPPI - DB
1661
MedChem Express Bioactive Compound Library
HY-B1305
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
chloropyramine-hydrochloride
TargetMol Bioactive Compound Library
T0263
The Spectrum Collection
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
289.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.3
TPSA
19.37
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Tyrosine Kinase/Adaptors
Angiogenesis
Cytoskeletal Signaling
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Target
FAK-VEGFR-3
H1 receptor
Ligand for Target Protein
HRH1
FAK
Histamine Receptor
VEGFR
Indication
edema, conjunctivitis, allergic rhinitis, asthma
Disease Area
cardiology, ophthalmology, allergy, pulmonary
MOA
Histamine Receptor antagonist
Solubility
Soluble in DMSO, not in water
Source data