General
Preferred name
TAFLUPROST
Synonyms
MK2452 ()
AFP-168 ()
AFP-168,MK2452 ()
Tafluprost-d4 ()
Zioptan ()
Saflutan ()
MK-2452 ()
P&D ID
PD009195
CAS
209860-87-7
Tags
available
prodrug
drug
Approved by
FDA
First approval
2012
Drug indication
Glaucoma/ocular hypertension
Open-angle glaucoma
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ABSORPTION
Following instillation, tafluprost is absorbed through the cornea and is hydrolyzed to the biologically active acid metabolite, tafluprost acid. Tafluprost is an ester which makes the drug lipophillic enough to be quickly absorbed through. When administered to the eye, the peak plasma concentration (Cmax) and time to peak plasma concentration (Tmax) of tafluprost acid in healthy subjects was 26 pg/mL and 10 minutes respectively. a; AUC, tafluprost acid = 394 pg*min/mL - 432 pg*min/mL.
METABOLISM
Tafluprost is an ester prodrug which is rapidly hydrolyzed by corneal esterases to form its biologically active acid metabolite. Tafluprost acid is further metabolized via fatty acid β-oxidation and phase II conjugation into 1,2,3,4-tetranor acid. ;
DESCRIPTION
Tafluprost is a prostaglandin analogue.
(GtoPdb)
DESCRIPTION
Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma[1][2][3][4][5].
PRICE
73
DESCRIPTION
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2??.
DESCRIPTION
Tafluprost is an ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
(Enamine Bioactive Compounds)
DESCRIPTION
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
452.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
2
Aromatic Ring Count
1
cLogP
4.68
TPSA
75.99
Fraction CSP3
0.56
Chiral centers
4.0
Largest ring
6.0
QED
0.27
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PGF2α
PTGFR
Prostaglandin Receptor
Indication
glaucoma, ocular hypertension
MOA
Prostaglandin inhibitor
Pathway
GPCR/G protein
Immunology/Inflammation
Source data
