General
Preferred name
LOMITAPIDE
Synonyms
BMS-201038 ()
AEGR-733 ()
Lomitapide (mesylate) ()
LOMITAPIDE MESYLATE ()
AEGR-733 mesylate ()
BMS-201038 mesylate ()
AEGR-733, BMS-201038 ()
AEGR-733 Mesylate,BMS-2138 Mesylate ()
Lojuxta ()
BMS-201038-01 ()
Aegr-733 mesilate ()
AEGR-733 MESYLATE ()
Juxtapid ()
BMS-201038-04 ()
Lomitapide mesilate ()
Lomitapide-d8 ()
P&D ID
PD009190
CAS
182431-12-5
202914-84-9
2459377-96-7
Tags
available
drug
Approved by
FDA
First approval
2012
Drug Status
investigational
approved
Drug indication
Familial hypercholesterolemia
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lomitapide is a lipid-lowering agent for the treatment of familial hypercholesterolemia. (GtoPdb)
DESCRIPTION Lomitapide Mesylate is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia. (BOC Sciences Bioactive Compounds)
Compound Sets
23
AdooQ Bioactive Compound Library
A12778
Axon Medchem Screening Library
2917
BOC Sciences Bioactive Compounds
lomitapide-mesylate-cas-202914-84-9-item-84-463457
Cayman Chemical Bioactives
10009610
28764
ChEMBL Approved Drugs
CHEMBL354541
CHEMBL2105662
ChEMBL Drugs
CHEMBL354541
CHEMBL2105662
Drug Repurposing Hub
DrugBank
DB08827
DrugBank Approved Drugs
DB08827
DrugCentral
4721
DrugCentral Approved Drugs
4721
DrugMAP
DMQTAGO
DrugMAP Approved Drugs
DMQTAGO
EU-OPENSCREEN Bioactive Compound Library
EOS101685
Guide to Pharmacology
7439
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL354541
Mcule NIBR MoA Box Subset
MCULE-1778342647
MedChem Express Bioactive Compound Library
HY-14667
HY-14668
NCATS Inxight Approved Drugs
82KUB0583F
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
lomitapide
lomitapide-mesylate
TargetMol Bioactive Compound Library
T6267
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
693.28
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
6
Aromatic Ring Count
4
cLogP
8.38
TPSA
61.44
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
MTP
MTTP
MTP inhibitor
Microsomal Triglyceride Transfer Protein (MTP)
Member status
member
MOA
Microsomal Triglyceride Transfer Protein (MTTP) Inhibitors
microsomal trigylceride transfer protein inhibitor
Indication
hypercholesterolemia
Source data