General
Preferred name
levomilnacipran
Synonyms
LEVOMILNACIPRAN HYDROCHLORIDE ()
Levomilnacipran HCl ()
Levomilnacipran (hydrochloride) ()
(1S,2R)-Milnacipran (hydrochloride) ()
F-2695 (hydrochloride) ()
Milnacipran ((1S-cis) hydrochloride) ()
F2695 ()
F-2695 HYDROCHLORIDE ()
F2695 HYDROCHLORIDE ()
Fetzima ()
(1s,2r)-milnacipran hydrochloride ()
F 2695 HYDROCHLORIDE ()
Milnacipran, (1s,2r)- ()
F-2695 ()
(1s,2r)-milnacipran ()
F 2695 ()
P&D ID
PD009171
CAS
96847-54-0
175131-60-9
Tags
available
drug
Approved by
FDA
First approval
2013
Drug indication
Major depressive disorder
Fibromyalgia
Nicotine dependence
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
33
ROE
Levomilnacipran and its metabolites are eliminated primarily by renal excretion. 58% of the dose is excreted in urine as unchanged levomilnacipran. N-desethyl levomilnacipran is the major metabolite; excreted in the urine and accounted for approximately 18% of the dose. Other identifiable metabolites excreted in the urine are levomilnacipran glucuronide (4%), desethyl-levomilnacipran glucuronide (3%), p-hydroxy levomilnacipran glucuronide (1%), and p-hydroxylevomilnacipran (1%). The metabolites are inactive.
DESCRIPTION
Levomilnacipran is the active enantiomer of . . It is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI).
(GtoPdb)
DESCRIPTION
Milnacipran (1S-cis) hydrochloride (Levomilnacipran Hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI), treatment of fibromyalgia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
246.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
1.77
TPSA
46.33
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
serotonin
Serotonin Transporter
SLC6A2, SLC6A4
SNRI
Akt
MTOR
P-glycoprotein
PI3K
Trk Receptor
Indication
fibromyalgia
MOA
serotonin–norepinephrine reuptake inhibitor (SNRI)
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
PI3K/Akt/mTOR
Protein Tyrosine Kinase/RTK
Source data
