General
Preferred name
DOLUTEGRAVIR
Synonyms
GSK1349572 ()
S/GSK1349572 ()
GSK-1349572A ()
DOLUTEGRAVIR SODIUM ()
Dolutegravir ()
Triumeq-dolutegravir ()
Dolutegravir (sodium) ()
S/GSK1349572 (sodium) ()
Dolutegravir (GSK1349572) ()
GSK1349572,S/GSK1349572,Tivicay ()
S-349572 ()
Tivicay ()
GSK-1349572 ()
GSK 1349572 ()
Tivicay pd ()
Dovato ()
Dolutegravir sodium salt ()
GSK1349572A ()
Dolutegravir-d5 ()
P&D ID
PD009167
CAS
1051375-16-6
1051375-19-9
Tags
available
drug
Approved by
PMDA
EMA
FDA
First approval
2013
Drug Status
approved
Drug indication
Human immunodeficiency virus infection
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dolutegravir is a viral integrase inhibitor class drug.
DESCRIPTION Dolutegravir is an HIV viral integrase inhibitor class drug. (GtoPdb)
Cell lines
0
Organisms
4
Compound Sets
21
AdooQ Bioactive Compound Library
A11068
Axon Medchem Screening Library
2855
Cayman Chemical Bioactives
22191
25755
ChEMBL Approved Drugs
CHEMBL1229211
CHEMBL1213165
ChEMBL Drugs
CHEMBL1229211
CHEMBL1213165
Drug Repurposing Hub
DrugBank
DB08930
DrugBank Approved Drugs
DB08930
DrugCentral
4805
DrugCentral Approved Drugs
4805
DrugMAP
DMCZGRE
DrugMAP Approved Drugs
DMCZGRE
EU-OPENSCREEN Bioactive Compound Library
EOS101330
Guide to Pharmacology
7365
MedChem Express Bioactive Compound Library
HY-13238
HY-13238A
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
DKO1W9H7M1
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
s-gsk1349572
dolutegravir-sodium
TargetMol Bioactive Compound Library
T6198
T2329
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
419.13
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
1.35
TPSA
100.87
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Target
HIV Integrase
CYP3A4, CYP3A5, CYP3A7, POU2F2, UGT1A1
HIV
Integrase
MOA
HIV Protease inhibitor
HIV integrase inhibitor
Indication
human immunodeficiency virus (HIV-1)
Therapeutic Indication
Antiviral
Source data