General
Preferred name
MACITENTAN
Synonyms
ACT-064992 ()
Macitentan?(ACT 064992) ()
ACT 064992 ()
Opsumit ()
Macitentan-d4 ()
P&D ID
PD009165
CAS
441798-33-0
1258428-05-5
Tags
available
drug
Approved by
EMA
FDA
First approval
2013
2010
Drug Status
approved
Drug indication
Cardiovascular disease
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY
Macitentan has a black box warning of embryo-fetal toxicity. Special precautions must be taken for all females of child-bearing age, and women who are pregnant must not be given macitentan. ;
DESCRIPTION
Macitentan is an endothelin receptor antagonist (ERA). It exhibits approximately 50-fold selectivity for the ETA receptor over the ETB receptor .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
23
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
585.96
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
11
Ring Count
3
Aromatic Ring Count
3
cLogP
3.57
TPSA
128.22
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Apoptosis
Target
ET-A
ET-B
EDNRA, EDNRB
Endothelin Receptor
Indication
contraceptive
MOA
Endothelin Receptor antagonist
Source data
