General
Preferred name
CHLORCYCLIZINE
Synonyms
(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) ()
CHLORCYCLIZINE HYDROCHLORIDE ()
1-(4-CHLORODIPHENYLMETHYL)-4-METHYLPIPERAZINE HYDROCHLORIDE ()
Chlorcyclizine hydrochloride (1:x) ()
Perazil ()
Histantin ()
NSC-169496 ()
AH-289 ()
Chlorcyclizine hcl ()
Di-Paralene ()
Chlorcyclizinium chloride ()
Chlorcyclizine monohydrochloride ()
Trihistan ()
COMPD 47-282 ()
Perazyl ()
NSC-25246 ()
Alergicide ()
Chlorcyclizine (hydrochloride) ()
P&D ID
PD009162
CAS
1620-21-9
82-93-9
14362-31-3
Tags
drug candidate
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
Drug indication
Hepatitis C virus infection
Max Phase
Phase 1
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chlorcyclizine is a first-generation Histamine Receptor antagonist of the phenylpiperazine class. It can be used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic. Chlorcyclizine also has some anticholinergic, antiserotonergic, and local anesthetic properties. It also has been studied as a potential treatment for hepatitis C. (BOC Sciences Bioactive Compounds)
DESCRIPTION The hydrochloride salt form of Chlorcyclizine which could be used as an antihistamine agent and is also found to have anticholinergic effect at some extent. (BOC Sciences Bioactive Compounds)
DESCRIPTION Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM). It is believed to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), targeting viral entry into host cells. Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
14
BOC Sciences Bioactive Compounds
chlorcyclizine-hydrochloride-1-x-cas-1620-21-9-item-60234
chlorcyclizine-hydrochloride-cas-14362-31-3-item-89538
chlorcyclizine-cas-82-93-9-item-78063
Cayman Chemical Bioactives
19239
ChEMBL Drugs
CHEMBL1889091
CHEMBL22150
DrugBank
DB08936
DrugBank Approved Drugs
DB08936
DrugCentral
593
DrugCentral Approved Drugs
593
DrugMAP
DM3L52Q
DrugMatrix
Ki Database
Chlorcyclizine
NCATS Inxight Approved Drugs
M26C4IP44P
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
300.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.68
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
Therapeutic Class
Antihistamines
Solubility
~10 mg/ml in PBS (pH 7.2).
Soluble in DMSO
Source data