General
Preferred name
ISOXSUPRINE
Synonyms
Hanegif ()
(R/S) ISOXSUPRINE HYDROCHLORIDE ()
Duvadilan ()
Isolait ()
ISOXSUPRINE HYDROCHLORIDE ()
Dilavase ()
Vadosilan ()
NSC-757067 ()
Vasodilan ()
Defencin ()
Duviculine ()
Vasotran ()
Navilox ()
Isoxsuprine hcl ()
Suprilent ()
Duvadilan Ret ()
Dilator ()
Isoxsuprine (hydrochloride) ()
Isoxsuprine-d6 (hydrochloride) ()
P&D ID
PD009161
CAS
579-56-6
34233-88-0
395-28-8
Tags
natural product
drug
available
Approved by
FDA
Drug Status
approved
withdrawn
Max Phase
Phase 4
Drug indication
Vasodilator
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Isoxsuprine is a β-adrenergic receptor agonist and α-adrenergic receptor. Isoxsuprine has been shown to relax vascular smooth muscle and can be used in the treatment of blood vessel diseases. It is also used in veterinary medicine for the treatment of navicular syndrome and laminitis in horses. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
15
BOC Sciences Bioactive Compounds
erythro-isoxsuprine-hydrochloride-cas-579-56-6-item-72139
Cayman Chemical Bioactives
20688
27847
ChEMBL Approved Drugs
CHEMBL559180
CHEMBL1197051
ChEMBL Drugs
CHEMBL559180
CHEMBL1197051
DrugCentral
1510
DrugCentral Approved Drugs
1510
DrugMatrix
MedChem Express Bioactive Compound Library
HY-B1270
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
isoxsuprine-hydrochloride
TargetMol Bioactive Compound Library
T0324
Withdrawn 2.0
DB08941
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
301.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.87
TPSA
61.72
Fraction CSP3
0.33
Chiral centers
3.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
??-adrenergic receptor
Adrenergic Receptor
iGluR
ATC
C04AA01
Toxicity type
NULL
Source data