General
Preferred name
IFENPRODIL
Synonyms
IFENPRODIL TARTRATE ()
Ifenprodil,(+/-) ()
RC 61-91 ()
RC-61-91 ()
RC61-91 ()
RC 6191 ()
Alpha 1-PI ()
NP-120 ()
Ifenprodil hemitartrate ()
Ifenprodil (hemitartrate) ()
P&D ID
PD009158
CAS
23210-58-4
23210-56-2
136172-79-7
Tags
available
probe
drug candidate
drug
Drug indication
Post-traumatic stress disorder
Cardiovascular disease
Alpha-1 antitrypsin deficiency
Cancer related pain
Drug Status
approved
withdrawn
investigational
Max Phase
2.0
1.0
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Ifenprodil (RC 61-91) is a noncompetitive NMDA receptor antagonist with anti-excitotoxic activity. Ifenprodil significantly improves long-term sensorimotor and spatial learning deficits in mice after acute subarachnoid hemorrhage. Ifenprodil reduces neuronal cell death in the basal cortex and CA1 region of the hippocampus induced by experimental subarachnoid hemorrhage. Ifenprodil attenuates Ca2+ overload in basal cortical cells and mitochondria, as well as brain edema in blood-brain barrier damage and early brain injury. Ifenprodil reduces the intracellular Ca2+ increase and apoptosis of primary cortical neurons under conditions of high glutamate concentrations. Ifenprodil also reduces the increase in endothelial permeability caused by high glutamate concentrations in human brain microvascular endothelial cells. Ifenprodil also inhibits GIRK channels and interacts with ¦Á1-adrenergic, 5-HT, and ¦Ò receptors[1].
PRICE
261
DESCRIPTION
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Ifenprodil is an NMDA receptor antagonist and acts at the polyamine site. It is also an α2 adrenergic receptor ligand. It is selective for σ2 ligand over σ1 sites. It is used as a neuroprotective agent and peripheral vasodilator.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibits GIRK channels and interacts with alpha1 adrenergic, serotonin, and sigma receptors.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Blocks the polyamine binding site associated with the NMDA glutamate receptor; neuroprotective
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
2
Compound Sets
25
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
69
Molecular Weight
325.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.77
TPSA
43.7
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Polyamine site NMDA
Target
NMDA
α2 adrenergic receptor
NMDA Receptor
Adrenergic Receptor
Calcium Channel
iGluR
Influenza Virus
Potassium Channel
NMDAR
Pathway
Membrane Transporter/Ion Channel
Neuroscience
GPCR/G protein
Anti-infection
Neuronal Signaling
MOA
NMDAR antagonist
NMDA Antagonists
alpha-Adrenoceptor Antagonists
Member status
virtual
ATC
C04AX28
Toxicity type
NULL
Source data
