General
Preferred name
COBICISTAT
Synonyms
GS-9350 ()
Tybost ()
Cobicistat(GS-9350) ()
Cobicistat (GS-9350) ()
Cobicistat on silicon dioxide ()
Cobicistat, (r,r,s)- ()
Cobicistat-d8 ()
P&D ID
PD009147
CAS
1004316-88-4
2699607-48-0
Tags
available
drug
Approved by
FDA
PMDA
EMA
First approval
2012
Drug indication
Human immunodeficiency virus infection
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This compound is approved as a component of the so-called 'Quad pill' (Stribild®), an anti-HIV therapy which contains cobicistat, elvitegravir, , and .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
775.35
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
3
Rotatable Bonds
19
Ring Count
5
Aromatic Ring Count
4
cLogP
6.0
TPSA
138.02
Fraction CSP3
0.47
Chiral centers
3.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Anti-infection
Metabolic Enzyme/Protease
Target
CYP3A
CYP3A4, CYP3A43, CYP3A5, CYP3A7
Cytochrome P450
HIV
P450 (e.g. CYP17)
Indication
human immunodeficiency virus (HIV-1)
MOA
Cytochrome P450 inhibitor
Source data
