General
Preferred name
PHENCYCLIDINE
Synonyms
Pcp, sernylan ()
PHENCYCLIDINE HYDROCHLORIDE ()
PCP (hydrochloride) ()
Tic tac ()
Angel dust ()
Phencycline ()
J4.441E ()
Fenciclidina ()
Phenylcyclidine ()
NSC-40902 ()
Sernylan ()
GP-121 ()
PCP ()
CN-25,253-2 ()
Phencyclidine hydrochloride cii ()
CI-395 ()
Pcp hydrochloride ()
Phencyclidine hcl ()
CN-25253-2 ()
P&D ID
PD009136
CAS
60124-79-0
77-10-1
101887-87-0
956-90-1
Tags
available
drug
drug candidate
Drug indication
Discovery agent
Drug Status
approved
investigational
illicit
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Phencyclidine works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA Receptor.;
MOA
The N-methyl-D-Aspartate (NMDA) receptor, a type of ionotropic receptor, is found on the dendrites of neurons and receives signals in the form of neurotransmitters. It is a major excitatory receptor in the brain. Normal physiological function requires that the activated receptor fluxes positive ions through the channel part of the receptor. PCP enters the ion channel from the outside of the neuron and binds, reversibly, to a site in the channel pore, blocking the flux of positive ions into the cell. PCP therefore inhibits depolarization of neurons and interferes with cognitive and other functions of the nervous system.;
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
18
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
243.2
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
4.33
TPSA
3.24
Fraction CSP3
0.65
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
NMDA Antagonists
Source data
