General
Preferred name
THIETHYLPERAZINE
Synonyms
Thietylperazine Malate ()
GS-95 ()
Thietylperazine Maleate ()
2-(Ethylthio)-10-(3-(4-methylpiperazin-1-yl)propyl)-10h-phenothiazine ()
Thiethylperazine malate ()
THIETHYLPERAZINE MALEATE ()
Thiethylperazine dimalate ()
Thiethylperazine (dimaleate) ()
Thiethylperazine dimalate ()
Torecan ()
NSC-130044 ()
Thiethylperazine dimaleate ()
P&D ID
PD009118
CAS
52239-63-1
1420-55-9
4627-00-3
1179-69-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1961
Drug Status
approved
withdrawn
Drug indication
Anti-Emetic
Nausea
Middle East Respiratory Syndrome (MERS)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thiethylperazine is a phenothiazine class antiemetic. Experiments in a mouse model suggest it may have potential to clear amyloid-β (Aβ) load in Alzheimer's disease . (GtoPdb)
Cell lines
0
Organisms
2
Compound Sets
17
ChEMBL Approved Drugs
CHEMBL2359670
CHEMBL1378
CHEMBL3989478
ChEMBL Drugs
CHEMBL2359670
CHEMBL1378
CHEMBL3989478
Drug Repurposing Hub
DrugBank
DB00372
DrugBank Approved Drugs
DB00372
DrugCentral
2630
DrugCentral Approved Drugs
2630
DrugMAP
DMQ0YB5
DMU3IET
DrugMAP Approved Drugs
DMU3IET
DrugMatrix
Guide to Pharmacology
7306
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201074
MedChem Express Bioactive Compound Library
HY-B1794
HY-B1794A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Withdrawn 2.0
DB00372
External IDs
62
Properties
(calculated by RDKit )
Molecular Weight
399.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
5.04
TPSA
9.72
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
DRD1, DRD2, DRD4
Amyloid-β
Bacterial
Dopamine Receptor
Histamine Receptor
Indication
nausea
MOA
Dopamine Receptor antagonist
ATC
R06AD03
Therapeutic Class
Antiemetics
Antiviral Agents
Pathway
Anti-infection
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data