General
Preferred name
THIETHYLPERAZINE
Synonyms
Thietylperazine Malate ()
GS-95 ()
Thietylperazine Maleate ()
2-(Ethylthio)-10-(3-(4-methylpiperazin-1-yl)propyl)-10h-phenothiazine ()
Thiethylperazine malate ()
Toresten ()
THIETHYLPERAZINE MALEATE ()
Norzine ()
Tietilperazina ()
Thiethylperazine dimalate ()
Thiethylperazine dimalate ()
Thiethylperazine (dimaleate) ()
Thiethylperazine dimaleate ()
Torecan ()
NSC-130044 ()
P&D ID
PD009118
CAS
52239-63-1
1420-55-9
4627-00-3
1179-69-7
Tags
available
drug
Approved by
FDA
First approval
1961
Drug indication
Nausea
Middle East Respiratory Syndrome (MERS)
Inguinal hernia
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thiethylperazine is a phenothiazine class antiemetic. Experiments in a mouse model suggest it may have potential to clear amyloid-β (Aβ) load in Alzheimer's disease . (GtoPdb)
DESCRIPTION Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-¦Â (A¦Â) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
PRICE 106
DESCRIPTION Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid ?? (A??) load in mice, is used to relieve vertigo, and can be used in studies of neurological diseases such as Alzheimer's disease and Parkinson's disease. Alzheimer's and Parkinson's diseases.
DESCRIPTION Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-¦Â (A¦Â) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
PRICE 83
DESCRIPTION Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice, is used to relieve vertigo, and can be used in studies of neurological diseases such as Alzheimer's disease and Parkinson's disease. Alzheimer's and Parkinson's diseases. (TargetMol Bioactive Compound Library)
DESCRIPTION Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic effects. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
18
ChEMBL Approved Drugs
CHEMBL2359670
CHEMBL1378
CHEMBL3989478
ChEMBL Drugs
CHEMBL2359670
CHEMBL1378
CHEMBL3989478
Drug Repurposing Hub
DrugBank
DB00372
DrugBank Approved Drugs
DB00372
DrugCentral
2630
DrugCentral Approved Drugs
2630
DrugMAP
DMQ0YB5
DMU3IET
DrugMAP Approved Drugs
DMU3IET
DrugMatrix
Guide to Pharmacology
7306
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201074
MedChem Express Bioactive Compound Library
HY-B1794
HY-B1794A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T61915
T17072
Withdrawn 2.0
DB00372
External IDs
67
Properties
(calculated by RDKit )
Molecular Weight
399.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
5.04
TPSA
9.72
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Microbiology/virology
Neuroscience
Anti-infection
Neuronal Signaling
Target
DRD1, DRD2, DRD4
Amyloid-β
Bacterial
Dopamine Receptor
Histamine Receptor
Amyloid-¦Â
D2 receptor
H1 receptor
ABCC
Antibacterial
D2
Aβ
Indication
nausea
MOA
Dopamine Receptor antagonist
ATC
R06AD03
Therapeutic Class
Antiemetics
Antiviral Agents
Source data