General
Preferred name
TACRINE
Synonyms
TACRINE HYDROCHLORIDE ()
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride ()
Tacrine hydrochloride hydrate ()
Tacrine (hydrochloride) ()
Tacrine HCl ()
1,2,3,4-tetrahydroacridin-9-amine ()
CI-970 ()
Alzyme ()
NSC-72108 ()
Cognex ()
Tacrinal ()
Tacrina ()
P&D ID
PD009117
CAS
321-64-2
1684-40-8
206658-92-6
Tags
available
drug
Approved by
FDA
First approval
1993
Drug indication
Alzheimer disease
cocaine dependence
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tacrine is a dual inhibitor of butyrylcholine esterase (P06276) and acetylcholinesterase (P22303). Marketed formulations may contain tacrine hydrochloride (PubChem CID 2723754). (GtoPdb)
DESCRIPTION Marketed formulations may contain tacrine hydrochloride (PubChem CID 2723754).
DESCRIPTION Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease[1][2][3][4].
PRICE 33
DESCRIPTION Tacrine (CS 12602) is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.
DESCRIPTION Cholinesterase inhibitor (Tocriscreen Total)
DESCRIPTION Cholinesterase inhibitor; reported to be useful ;in the treatment of Alzheimer's disease (LOPAC library)
DESCRIPTION Tacrine hydrochloride is a potent cholinesterase inhibitor used for the treatment of memory deficits in patients with Alzheimers's disease. Tacrine hydrochloride has been shown to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and reduces depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION Tacrine is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. (Enamine Bioactive Compounds)
DESCRIPTION Inhibition constant determined against Acetylcholinesterase (AChE) receptor.; Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate incubated for 15 mins followed by substrate addition by Ellman's method (TargetMol Bioactive Compound Library)
DESCRIPTION Tacrine is a centerally active acetylcholinesterase inhibitor. It has been approved for the treatment of Alzheimer's disease and other central nervous system disorders. (BOC Sciences Bioactive Compounds)
Cell lines
6
Organisms
5
Compound Sets
37
BOC Sciences Bioactive Compounds
tacrine-hydrochloride-cas-1684-40-8-item-204761
tacrine-hydrochloride-hydrate-cas-206658-92-6-292428
Cayman Chemical Bioactives
70240
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1677
CHEMBL95
ChEMBL Drugs
CHEMBL1677
CHEMBL95
Concise Guide to Pharmacology 2017/18
6687
Concise Guide to Pharmacology 2019/20
6687
Concise Guide to Pharmacology 2021/22
6687
Concise Guide to Pharmacology 2023/24
6687
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00382
DrugBank Approved Drugs
DB00382
DrugCentral
2551
DrugCentral Approved Drugs
2551
DrugMAP
DM51FY6
DrugMAP Approved Drugs
DM51FY6
DrugMatrix
Enamine Bioactive Compounds
EBC-06032
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS102074
Guide to Pharmacology
6687
Ki Database
Tacrine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1677
CHEMBL95
MedChem Express Bioactive Compound Library
HY-B1488
HY-111338
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
tacrine-hcl
TargetMol Bioactive Compound Library
C066-2825
The Spectrum Collection
Tocriscreen Total
Withdrawn 2.0
DB00382
ZINC Tool Compounds
ZINC000019014866
External IDs
74
Properties
(calculated by RDKit )
Molecular Weight
198.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
2
cLogP
2.7
TPSA
38.91
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cholinesterase
MOA
Acetylcholinesterase inhibitor
Acetylcholinesterase Inhibitors
Butyrylcholinesterase Inhibitors
Target
Cholinesterases
ACHE & BCHE
ACHE, BCHE
Cholinesterase (ChE)
iGluR
AChR
Member status
member
Indication
Alzheimer's disease
ATC
N06DA01
Therapeutic Class
Parasympathomimetics
Pathway
Neuronal Signaling
Membrane Transporter/Ion Channel
Source data