General
Preferred name
METHARBITAL
Synonyms
Metharbitone ()
Metarbital ()
NSC-27156 ()
Metharbital ciii ()
Gemonil ()
P&D ID
PD009113
CAS
50-11-3
Tags
available
drug
Approved by
FDA
Drug indication
Epilepsy
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Metharbital is a barbiturate anticonvulsant. (GtoPdb)
Compound Sets
13
ChEMBL Approved Drugs
CHEMBL450
ChEMBL Drugs
CHEMBL450
Drug Repurposing Hub
DrugBank
DB00463
DrugCentral
1740
DrugCentral Approved Drugs
1740
DrugMAP
DM5A38V
DrugMAP Approved Drugs
DM5A38V
DrugMatrix
Guide to Pharmacology
7230
NPC Screening Collection
ReFrame library
Withdrawn 2.0
DB00463
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
198.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
0
cLogP
0.5
TPSA
66.48
Fraction CSP3
0.67
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Indication
epilepsy
Target
CHRNA4, CHRNA7, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA2, GRIK2
MOA
GABA Receptor modulator
ATC
N03AA30
Therapeutic Class
Anticonvulsants
Source data