General
Preferred name
TRIDIHEXETHYL
Synonyms
TRIDIHEXETHYL IODIDE ()
TRIDIHEXETHYL CHLORIDE ()
Pathilon ()
Tridihexethyl ion ()
Tridihexethyl cation ()
Tridihexide ()
Trihexethyl iodide ()
Propethonium iodide ()
Claviton ()
Tridihexethide ()
P&D ID
PD009112
CAS
4310-35-4
60-49-1
125-99-5
Tags
available
drug candidate
drug
Approved by
FDA
First approval
1954
Drug indication
Acquired nystagmus
Drug Status
approved
withdrawn
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tridihexethyl is a synthetic anticholinergic agent. It has a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. lt binds the muscarinic acetylcholine receptor and may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart and M-3 receptors at the parasympathetic NEJ system. lt inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. lt is an anticholinergic, antimuscarinic and antispasmodic drug. It may be used to treat acquired nystagmus or peptic ulcer disease in combination with other drugs.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
318.28
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
4.72
TPSA
20.23
Fraction CSP3
0.71
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Anticholinergic Agents
Solubility
Soluble in DMSO, not in water
Source data
