General
Preferred name
BENTIROMIDE
Synonyms
BTPABAPFT ()
BTPABA PFT ()
Chymex ()
BTPABA-PFT ()
E-2663 ()
Bentiromida ()
BTPABA, PFT ()
Pfd ()
P&D ID
PD009111
CAS
37106-97-1
Tags
available
drug
Approved by
FDA
First approval
1983
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. The amount of p-aminobenzoic acid and its metabolites excreted in the urine is the quantitative measure of the chymotrypsin-secreting activity of the pancreas.
INDICATION Indicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
Compound Sets
12
ChEMBL Approved Drugs
CHEMBL1200368
ChEMBL Drugs
CHEMBL1200368
Drug Repurposing Hub
DrugBank
DB00522
DrugCentral
316
DrugCentral Approved Drugs
316
Mcule NIBR MoA Box Subset
MCULE-5945221970
MedChem Express Bioactive Compound Library
HY-B1493
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
bentiromide
Withdrawn 2.0
DB00522
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
404.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
3.07
TPSA
115.73
Fraction CSP3
0.09
Chiral centers
1.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Pancreatic trypsin inhibitor
Indication
pancreas diagnostic agent
Target
HPN
ATC
V04CK03
Source data