General
Preferred name
BENZQUINAMIDE
Synonyms
P2647 ()
BZQ ()
Benzoquinamide ()
3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride ()
BENZQUINAMIDE HYDROCHLORIDE ()
Benzoquinamide hydrochloride ()
BENZQUINAMIDA ()
NSC-169193 ()
NSC-108159 ()
P-2647 ()
Quantril ()
PROMECON ()
BENZCHINAMIDE ()
NSC-64375 ()
Benzquinamide HCl ()
Emete-con ()
QUANTRIL ()
Benzquinamide (hydrochloride) ()
P&D ID
PD009110
CAS
23844-24-8
63-12-7
113-69-9
Tags
available
drug
Approved by
FDA
First approval
1974
Drug indication
Nausea
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Benzquinamide is a largely discontinued antiemetic drug.
(GtoPdb)
PRICE
1000
DESCRIPTION
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzquinamide for ??2A, ??2B, and ??2C adrenergic receptor (??2-AR) were 1,365, 691, and 545 nM, respectively. 545 nM, respectively.
PRICE
212
DESCRIPTION
Benzquinamide hydrochloride is an antiemetic compound with antihistaminic, anticholinergic and sedative properties. The mechanism of action is not quite sure and problely benzquinamide works through antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic agent and increases intra-arterial pressure due to the increased peripheral vascular resistance.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EUbOPEN Chemogenomics Library
Guide to Pharmacology
ReFrame library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
404.23
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
1
cLogP
2.42
TPSA
68.31
Fraction CSP3
0.64
Chiral centers
3.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
GPCR/G protein
Target
Adrenergic Receptor
Dopamine D2 receptor
MOA
Unknown molecular target
ATC
A
Therapeutic Class
Antiemetics
Solubility
Soluble in DMSO
Recommended Cell Concentration
None
Source data
