General
Preferred name
BENZQUINAMIDE
Synonyms
P2647 ()
BZQ ()
Benzoquinamide ()
BENZQUINAMIDE HYDROCHLORIDE ()
NSC-108159 ()
Promecon ()
Quantril ()
Benzchinamide ()
Emete-con ()
P-2647 ()
NSC-169193 ()
NSC-64375 ()
Benzquinamide HCl ()
P&D ID
PD009110
CAS
23844-24-8
63-12-7
113-69-9
Tags
available
drug
Approved by
FDA
First approval
1974
Drug indication
Anti-Emetic
Nausea
Drug Status
approved
withdrawn
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Benzquinamide is a largely discontinued antiemetic drug.
(GtoPdb)
DESCRIPTION
Benzquinamide hydrochloride is an antiemetic compound with antihistaminic, anticholinergic and sedative properties. The mechanism of action is not quite sure and problely benzquinamide works through antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
404.23
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
1
cLogP
2.42
TPSA
68.31
Fraction CSP3
0.64
Chiral centers
3.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
GPCR/G protein
Target
Adrenergic Receptor
Dopamine D2 receptor
MOA
Unknown molecular target
ATC
A
Therapeutic Class
Antiemetics
Solubility
Soluble in DMSO
Source data
