General
Preferred name
TEMAFLOXACIN
Synonyms
Omniflox ()
TMFX ()
TA-167 (free acid) ()
A-62254 (free acid) ()
TEMAFLOXACIN HYDROCHLORIDE ()
Teflox ()
Temafloxacin hcl ()
Teflox 400 ()
ABBOTT-62254 ()
Temafloxacine ()
Temafloxacino ()
P&D ID
PD009102
CAS
105784-61-0
108319-06-8
Tags
available
drug
Drug indication
bacterial disease
Bacterial infection
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
1992
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Temafloxacin is a fluoroquinolone antibiotic drug, marketed as Omniflox by Abbot Laboratories, which was withdrawn from the market in 1992 due to fatal adverse effects. Flouroquinolones such as lomefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter.
TOXICITY
Severe allergic reactions and hemolytic anemia were observed during the first few months of use leading to fatalities and the drug's eventual withdrawal from the market.
DESCRIPTION
Temafloxacin (A-62254) is a fluoroquinolone antibacterial .
(GtoPdb)
PRICE
112
DESCRIPTION
Temafloxacin is a fluoroquinolone antibiotic effective against gram-positive and gram-negative bacteria. It potently inhibits DNA topoisomerase.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Temafloxacin (Omniflox) is an antibiotic and antimycobacterial agent. It used to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
417.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
2.9
TPSA
74.57
Fraction CSP3
0.24
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
ATC
J01MA05
Toxicity type
hepatic, renal, dermatological, hematological
Pathway
Microbiology/virology
Anti-infection
Source data
