General
Preferred name
NOMIFENSINE
Synonyms
Hoe98 ()
NOMIFENSINE MALEATE ()
(¡À)-Nomifensine maleat ()
(¡À)-Nomifensin ()
(??)-Nomifensin ()
(??)-Nomifensine maleat ()
Nomifensine (maleate) ()
(±)-Nomifensin ()
(±)-Nomifensine maleat ()
Hostalival ()
Psicronizer ()
Nomifensine hydrogen maleate ()
NSC-289114 ()
Merital ()
HOE 984 ()
HOE-984 ()
Nomifensin ()
Linamiphen ()
P&D ID
PD009097
CAS
24526-64-5
32795-47-4
118184-50-2
89664-19-7
89664-20-0
Tags
natural product
drug
available
Approved by
FDA
Drug Status
approved
withdrawn
Drug indication
Antidepressant
Breast cancer
Max Phase
Phase 4
First approval
1984
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nomifensine is a norepinephrine-dopamine reuptake inhibitor. Bioactivity is reported to lie with the (S) isomer. (GtoPdb)
DESCRIPTION Dopamine reuptake inhibitor; antidepressant (LOPAC library)
DESCRIPTION Potent and selective noradrenalin re-uptake inhibitor (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
26
Cayman Chemical Bioactives
29330
ChEMBL Approved Drugs
CHEMBL1256842
CHEMBL273575
ChEMBL Drugs
CHEMBL1256842
CHEMBL273575
Concise Guide to Pharmacology 2017/18
4792
Concise Guide to Pharmacology 2019/20
4792
Concise Guide to Pharmacology 2021/22
4792
Concise Guide to Pharmacology 2023/24
4792
DrugBank
DB04821
DrugBank Approved Drugs
DB04821
DrugCentral
1958
DrugCentral Approved Drugs
1958
DrugMAP
DMCP2TS
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100582
Guide to Pharmacology
4792
Ki Database
NOMIFENSINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL273575
MedChem Express Bioactive Compound Library
HY-B1110A
HY-B1110
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T7308
Tocris Bioactive Compound Library
1992
Withdrawn 2.0
w165
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
238.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
2.85
TPSA
29.26
Fraction CSP3
0.25
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
dopamine reuptake
Dopamine Receptor
Primary Target
Dopamine Transporters
MOA
Inhibitor
Dopamine Reuptake Inhibitors
Norepinephrine Reuptake Inhibitors
Member status
member
ATC
N06AX04
Toxicity type
hematological
Source data