General
Preferred name
OXELADIN
Synonyms
OXELAIDIN CITRATE ()
2-(2-Diethylaminoethoxy)ethyl 2-ethyl-2-phenylbutyrate ()
Oxeladin citrate salt ()
Oxeladin (citrate) ()
OL ()
Oxeladin Citrate ()
Oxeladina ()
Oxeladine ()
P&D ID
PD009096
CAS
52432-72-1
468-61-1
16485-39-5
Tags
available
drug
Drug Status
withdrawn
approved
Max Phase
4.0
Drug indication
Cough
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Oxeladin citrate is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (Ki = 25 nM). Oxeladin can be used for pulmonary diseases and stroke research[1][2].
PRICE 29
DESCRIPTION Oxeladin citrate is a highly potent and effective cough suppressant, which can treat all types of cough of various etiologies. It is not related to opium or its derivatives, so treatment with oxeladin is no risk of addiction. And it has none of the side effects (such as hypnosis, respiratory depression, tolerance, constipation and analgesia) which are present when common antitussives. It can used at every age, as well as in patients with heart disease, since it is high level of safety and a great selectivity to act on the bulbar centre of cough. (TargetMol Bioactive Compound Library)
Compound Sets
15
ChEMBL Approved Drugs
CHEMBL1500276
ChEMBL Drugs
CHEMBL1500276
Drug Repurposing Hub
DrugBank
DB04822
DrugBank Approved Drugs
DB04822
DrugCentral
2018
DrugCentral Approved Drugs
2018
DrugMatrix
MedChem Express Bioactive Compound Library
HY-B1216
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
oxeladin-citrate
TargetMol Bioactive Compound Library
T0056
The Spectrum Collection
Withdrawn 2.0
w61
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
335.25
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
12
Ring Count
1
Aromatic Ring Count
1
cLogP
3.65
TPSA
38.77
Fraction CSP3
0.65
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
cough suppressant
MOA
antitussive
ATC
R05DB09
Toxicity type
carcinogenicity
Target
Sigma Receptor
Pathway
Neuronal Signaling
Source data