General
Preferred name
BENFLUOREX
Synonyms
BENFLUOREX HYDROCHLORIDE ()
JP-992 hydrochloride ()
Benfluorex (hydrochloride) ()
JP-992 (hydrochloride) ()
NSC-757396 ()
Mediaxal ()
P&D ID
PD009068
CAS
23602-78-0
23642-66-2
Tags
available
drug
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
diabetes mellitus
First approval
1974
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4¦Á) activator.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
351.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
4.08
TPSA
38.33
Fraction CSP3
0.32
Chiral centers
1.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
A10BX06
Toxicity type
cardiovascular
Pathway
GPCR/G protein
Source data
