General
Preferred name
CHLORTETRACYCLINE
Synonyms
CHLORTETRACYCLINE HYDROCHLORIDE ()
Isphamycin ()
Chlortetracycline HCl ()
7-Chlorotetracycline hydrochloride ()
Chlortetracycline (hydrochloride) ()
7-Chlorotetracycline (hydrochloride) ()
Chlorotetracycline ()
CHLORTETRACYCLINE BISULFATE ()
CHLORTETRACYCLINE CALCIUM ()
Aureomycin monohydrochloride ()
NSC-13252 ()
Isaphamycin ()
Aureomycin ()
Aureomicina ()
Chlortet HCl ()
Chlortetracyclini hydrochloridum ()
E702 ()
Clortetraciclina ()
Calcium chlortetracycline ()
Chlortetracycline calcium complex ()
Calcium-chlortetracycline complex ()
Chlorotetracycline calcium salt ()
Chlortetracycline bisulphate ()
P&D ID
PD009058
CAS
64-72-2
57-62-5
Tags
available
drug
natural product
drug candidate
Approved by
FDA
First approval
1950
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
infection
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Chlortetracycline is a tetracycline antibacterial, originally isolated from Kitasatospora aureofaciens (formerly Streptomyces aureofaciens), and the first compound from this class to be discovered . Note that the structure shown here matches the CAS-assigned structure. The PubChem link, provided in the table below, is to their standardized chemical structure (CID 54675777), although this is not an exact structural match.
(GtoPdb)
DESCRIPTION
Chlortetracycline Hydrochloride is a tetracycline with broad-spectrum antibacterial and antiprotozoal activity. Chlortetracycline hydrochloride (Isphamycin) is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative organisms, spirochetes, rickettsial species, certain protozoa and Mycoplasma and Chlamydia organisms.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
55
Molecular Weight
478.11
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
6
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
0.44
TPSA
181.62
Fraction CSP3
0.41
Chiral centers
5.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
30S ribosome
antibiotic
Bacterial
Parasite
MOA
ribosome inhibitor
ATC
A01AB21
D06AA02
J01AA03
S01AA02
G51AA08
J51AA03
Pathway
Microbiology/virology
Anti-infection
Source data
