General
Preferred name
Podophyllin
Synonyms
P&D ID
PD009057
CAS
8050-60-0
9000-55-9
Tags
available
drug
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY 1. LD50 (IV) Rat: 8.7 mg/kg 2. LD50 (IP) Rat: 15 mg/kg 3. LD50 (SC) Rat: 8 mg/kg 4. LD50 (IM) Rat: 3 mg/kg 5. LD50 (IP) Mouse: 30 mg/kg 6. LD50 (SC) Mouse: 24.6 mg/kg While podophyllin, the herbal extract from which podophyllotoxin is derived, can cause enteritis and potentially fatal CNS depression, podophyllotoxin has been shown to be safe, with minimal toxicity even in large doses. Application can be immediately followed by burning or itching. Small sores, itching and peeling skin can also follow.
ABSORPTION Oral absorption: Podophyllum is very well and rapidly absorbed after ingestion. Dermal absorption: systemic poisoning was reported after topical application in some cases. Symptoms were delayed between 2-24 hr.
TOXICITY 1. LD50 (IV) Rat: 8.7 mg/kg; 2. LD50 (IP) Rat: 15 mg/kg; 3. LD50 (SC) Rat: 8 mg/kg; 4. LD50 (IM) Rat: 3 mg/kg; 5. LD50 (IP) Mouse: 30 mg/kg; 6. LD50 (SC) Mouse: 24.6 mg/kg; ; While podophyllin, the herbal extract from which podophyllotoxin is derived, can cause enteritis and potentially fatal CNS depression, podophyllotoxin has been shown to be safe, with minimal toxicity even in large doses. Application can be immediately followed by burning or itching. Small sores, itching and peeling skin can also follow.
ABSORPTION Oral absorption: Podophyllum is very well and rapidly absorbed after ingestion.; Dermal absorption: systemic poisoning was reported after topical application in some cases. Symptoms were delayed between 2-24 hr.
Compound Sets
2
DrugBank
DB09094
DrugBank Approved Drugs
DB09094
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
1692.55
Hydrogen Bond Acceptors
32
Hydrogen Bond Donors
8
Rotatable Bonds
20
Ring Count
18
Aromatic Ring Count
8
cLogP
8.68
TPSA
433.18
Fraction CSP3
0.41
Chiral centers
16.0
Largest ring
6.0
QED
0.03
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data