General
Preferred name
DACLATASVIR DIHYDROCHLORIDE
Synonyms
BMS-790052 dihydrochloride ()
Daclatasvir (dihydrochloride) ()
BMS-790052 (dihydrochloride) ()
EBP 883 (dihydrochloride) ()
Daklinza ()
BMS-790052-05 ()
BMS 790052-05 ()
Daclatasvir hydrochloride ()
P&D ID
PD009052
CAS
1009119-64-5
1009119-65-6
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
chronic hepatitis C virus infection
First approval
2014
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 ¦ÌM and 3.27 ¦ÌM, respectively[1][2][3].
PRICE
47
DESCRIPTION
Daclatasvir is a direct-acting antiviral agent used to treat specific hepatitis C virus infections in combination with other antiviral agents.
(Enamine Bioactive Compounds)
DESCRIPTION
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antivirals to treat chronic hepatitis C. Elevations in serum enzyme levels during daclatasvir therapy are uncommon, and it has not been convincingly implicated in cases of clinically apparent liver injury with jaundice.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
Axon Medchem Screening Library
ChEMBL Approved Drugs
ChEMBL Drugs
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
810.34
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
11
Ring Count
6
Aromatic Ring Count
4
cLogP
7.07
TPSA
174.64
Fraction CSP3
0.45
Chiral centers
4.0
Largest ring
6.0
QED
0.12
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HCV
HCV NS5A
HCV NS5A protein inhibitor
HCV Protease
Pathway
Anti-infection
Microbiology/virology
Proteases/Proteasome
Source data
